Abstract | CONTEXT: OBJECTIVE: Our objective was to compare sst and D₂R expression levels between adenomas from patients with elevated and normalized preoperative urinary free cortisol excretion. PATIENTS AND DESIGN:
Corticotroph adenoma tissue was examined from patients from group 1 (n = 22; elevated preoperative urinary free cortisol) and group 2 (n = 11; mean duration of preoperative normocortisolism 10 weeks). Somatotroph adenoma tissue from 10 acromegalic patients was examined to compare receptor expression profiles. MAIN OUTCOME MEASURES: RESULTS: The sst₂ mRNA expression in group 2 was 10-fold higher than in group 1 (P < .01), even comparable to that in somatotroph adenomas. There were no statistically significant differences in sst₅ and D₂R mRNA expression or in sst₂, sst₅, and D₂R protein expression between both groups of corticotroph adenomas. In responders, octreotide (n = 2 out of 4; -30.5% ± 10.4%) was less potent than pasireotide (n = 5 out of 6; -47.0% ± 4.2%) and cabergoline (n = 3 out of 4; -41.9% ± 3.1%) with respect to inhibition of ACTH secretion by adenomas from group 2. CONCLUSIONS:
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Authors | R van der Pas, R A Feelders, F Gatto, C de Bruin, A M Pereira, P M van Koetsveld, D M Sprij-Mooij, A M Waaijers, F Dogan, S Schulz, J M Kros, S W J Lamberts, L J Hofland |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 12
Pg. E1880-90
(Dec 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 24081741
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents
- DRD2 protein, human
- Dopamine Agonists
- Dopamine D2 Receptor Antagonists
- Neoplasm Proteins
- Protein Isoforms
- Receptors, Dopamine D2
- Receptors, Somatostatin
- SSTR2 protein, human
- Somatostatin
- Hydrocortisone
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Topics |
- ACTH-Secreting Pituitary Adenoma
(drug therapy, metabolism, pathology, physiopathology)
- Adolescent
- Adrenal Glands
(drug effects, metabolism)
- Adult
- Aged
- Antineoplastic Agents
(pharmacology)
- Dopamine Agonists
(pharmacology)
- Dopamine D2 Receptor Antagonists
- Female
- Gene Expression Regulation
(drug effects)
- Humans
- Hydrocortisone
(metabolism, urine)
- Male
- Middle Aged
- Neoplasm Proteins
(agonists, antagonists & inhibitors, genetics, metabolism)
- Pituitary ACTH Hypersecretion
(etiology, prevention & control)
- Pituitary Gland
(drug effects, metabolism, pathology)
- Protein Isoforms
(genetics, metabolism)
- Receptors, Dopamine D2
(genetics, metabolism)
- Receptors, Somatostatin
(agonists, antagonists & inhibitors, genetics, metabolism)
- Somatostatin
(analogs & derivatives, pharmacology)
- Tumor Cells, Cultured
- Young Adult
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