Abstract | BACKGROUND: OBJECTIVES: SEARCH METHODS: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles and reviews. Last search: 21 January 2013.We searched the ongoing trial registry clinicaltrials.gov for any ongoing trials. Latest search for clinicaltrials.gov: 22 February 2013. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data and assessed the risk of bias in the included study. They planned to perform data analysis using Review Manager 5.1. MAIN RESULTS: Only one trial enrolling 14 patients was eligible for inclusion in the review. The study was terminated prematurely and complete data were not available. We contacted the study investigator and were told that the study was terminated due to the inability to recruit patients into the study despite all reasonable attempts. One or more serious side effects were encountered in six out of nine (66.67%) and one out of five (20%) patients in omalizumab group and placebo group respectively. AUTHORS' CONCLUSIONS:
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Authors | Kana R Jat, Dinesh K Walia, Anju Khairwa |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 9
Pg. CD010288
(Sep 17 2013)
ISSN: 1469-493X [Electronic] England |
PMID | 24043500
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Anti-Allergic Agents
- Antibodies, Anti-Idiotypic
- Antibodies, Monoclonal, Humanized
- anti-IgE antibodies
- Omalizumab
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Topics |
- Anti-Allergic Agents
(adverse effects, therapeutic use)
- Antibodies, Anti-Idiotypic
(adverse effects, therapeutic use)
- Antibodies, Monoclonal, Humanized
(adverse effects, therapeutic use)
- Aspergillosis, Allergic Bronchopulmonary
(drug therapy, etiology)
- Cystic Fibrosis
(complications)
- Early Termination of Clinical Trials
- Humans
- Omalizumab
- Randomized Controlled Trials as Topic
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