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Itraconazole (Sporanox)

Subscribe to New Research on Itraconazole

A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Also Known As:

Sporanox; Janssen Brand of Itraconazole; Janssen-Cilag Brand of Itraconazole; Orungal; R-51211; Itraconazole Janssen Brand; Janssen Cilag Brand of Itraconazole; R 51211; R51211; 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-

Networked: 2287 relevant articles (474 outcomes, 354 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Triazoles: 187
      - Itraconazole: 2287
        hydroxyitraconazole: 3
        cyclodextrin itraconazole: 1
  - Piperazines: 18
    - Itraconazole: 2287
      - hydroxyitraconazole: 3
      - cyclodextrin itraconazole: 1

Experts

1.	Gupta, A K: 18 articles (03/2009 - 01/2000)
2.	Gupta, Aditya K: 17 articles (05/2015 - 05/2002)
3.	Guarro, Josep: 8 articles (08/2015 - 09/2002)
4.	Kontoyiannis, Dimitrios P: 8 articles (09/2013 - 10/2002)
5.	Glasmacher, Axel: 8 articles (11/2011 - 12/2003)
6.	Verweij, Paul E: 7 articles (05/2009 - 06/2002)
7.	Wheat, L J: 7 articles (12/2001 - 06/2000)
8.	De Beule, K: 7 articles (10/2001 - 07/2000)
9.	Chakrabarti, Arunaloke: 6 articles (07/2015 - 11/2004)
10.	Cornely, Oliver A: 6 articles (01/2015 - 12/2006)

Related Diseases

1.	Infection 07/01/1997 - " non comparable clinical trials, Itraconazole was shown to be extremely effective in a wide range of superficial and more serious deep fungal infections when administered once or twice daily. " 03/01/1989 - "It is a potent inhibitor of most human fungal pathogens including Aspergillus sp. In non-comparative clinical trials itraconazole was shown to be extremely effective in a wide range of superficial and more serious 'deep' fungal infections when administered once or twice daily. " 09/01/1998 - "Additionally, studies have demonstrated that itraconazole may have increased efficacy and an excellent safety profile when administered in a pulse-dose, or intermittent fashion, for superficial mycotic infections. " 12/01/2006 - "Itraconazole intravenously followed by oral capsules is thus tolerated and effective in severely ill patients with proven invasive fungal infection." 01/01/2003 - "The infection cleared after complete surgical excision and 6 months of oral itraconazole therapy. "
2.	Onychomycosis (Tinea Unguium) 12/01/1998 - "In conclusion, intermittent itraconazole therapy is highly effective and safe in patients with onychomycosis." 12/01/2012 - "The purpose of the present study was to design and evaluate the potential of microemulsion-based gel as colloidal carrier for itraconazole for delivery into onycholytic nails for effective treatment of onychomycosis. " 10/01/2009 - "Itraconazole, while an effective treatment for onychomycosis, is not a first-choice therapy due to its black-box cardiac warning and numerous drug interactions. " 09/01/2005 - "Itraconazole may be effective in the treatment of onychomycosis caused by F. " 11/01/2003 - "Itraconazole was found to be effective, well-tolerated and safe therapy for disto-lateral subungual onychomycosis."
3.	Aspergillosis 06/01/2006 - "Because detection rate of the fungus is very low, itraconazole in combination with surgical excision of focus is the best treatment of lung and brain invasive aspergillosis." 03/01/1994 - "The data indicate that itraconazole is highly effective in preventing true invasive aspergillosis. " 10/01/1999 - "The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults)." 12/01/1995 - "Serum concentrations of the drug ranged from 2 micrograms/mL to 30 micrograms/mL. Review of 20 cases of cerebral aspergillosis that were treated with itraconazole revealed that three of the four patients who received high doses (800 mg/d in the adults) of the drug responded favorably, while only two of the 16 patients who received a dose of 400 mg/d were cured. " 10/15/2001 - "Overall iv/oral itraconazole was safe and effective in invasive aspergillosis."
4.	Acquired Immunodeficiency Syndrome (AIDS) 06/01/1997 - "Itraconazole cyclodextrin solution achieves higher serum itraconazole and hydroxy-itraconazole concentrations than the capsule formulation in AIDS patients, and this is associated with improved efficacy." 10/01/1999 - "Itraconazole solution can be effective in AIDS patients with C. " 07/01/2015 - "A computerised literature search was carried out using the PubMed, EMbase, Ovid, Web of Science, Science Direct and CNKI (China National Knowledge Infrastructure) databases to collect relevant articles (from their establishment date to August 2014) using the following keywords: Itraconaz or Sporanox, HIV, AIDS, Penicillium marneffei (PSM), and Treatment. " 02/01/2014 - "This paper presents a 35-year-old Brazilian male AIDS patient who developed pulmonary PCM successfully treated with itraconazole. " 04/01/2001 - "DNA fingerprinting of serial Candida albicans isolates obtained during itraconazole prophylaxis in patients with AIDS."
5.	Sporotrichosis 01/01/2008 - "Itraconazole is a triazole derivative leading to good results in the treatment of sporotrichosis. " 11/01/1989 - "Third, it suggests that itraconazole has significant promise in treating systemic sporotrichosis." 04/01/2015 - "The first therapeutic choice for the treatment of cutaneous sporotrichosis is oral itraconazole; however, the increase in cases of zoonotic transmission outbreak necessitates a search for effective and safe treatment alternatives. " 01/01/2008 - "Intermittent or pulsed itraconazole was effective in treating cutaneous sporotrichosis. " 05/01/1992 - "These results show that itraconazole represents a safe and effective drug for the treatment of sporotrichosis. "

Related Drugs and Biologics

1.	Fluconazole (Zonal)
2.	terbinafine (Lamisil)
3.	Amphotericin B (Amphotericin)
4.	Ketoconazole (Nizoral)
5.	posaconazole
6.	voriconazole (Vfend)
7.	Flucytosine (Ancobon)
8.	Griseofulvin (Grifulvin V)
9.	liposomal amphotericin B
10.	Itraconazole (Sporanox)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Oral Administration
4.	Stem Cell Transplantation
5.	Transplantation (Transplant Recipients)