Polycystic ovary syndrome is associated with P-wave prolongation and increased P-wave dispersion.

Abstract

BACKGROUND:

The polycystic ovary syndrome (PCOS) is associated with various cardiac manifestations including cardiac arrhythmias. P-wave dispersion (Pdis) is an appealing marker for predicting the risk of developing atrial arrhythmias. The purpose of this study was to evaluate P-wave durations and Pdis in patients with PCOS.

METHODS:

Forty adult patients with PCOS and 46 age- and sex-matched healthy individuals were included in this study. P-wave maximum duration (Pmax) and P-wave minimum duration (Pmin) were calculated on the 12-lead electrocardiogram, and the difference between the Pmax and the Pmin was defined as Pdis. All individuals also underwent transthoracic echocardiographic evaluation.

RESULTS:

Pmax and Pdis were significantly higher in patients with PCOS compared with controls (p = 0.007, p < 0.001, respectively). There was no difference in Pmin duration between both the groups (p = 0.2). Waist-to-hip ratio, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were higher in the PCOS group. Early mitral inflow deceleration time (DT) (p < 0.001) and isovolumetric relaxation time (p = 0.003) were longer in PCOS group. Waist-to-hip ratio, DT, E/A ratio and diastolic blood pressure correlated with Pdis.

CONCLUSIONS:

Patients with PCOS have prolonged Pmax and Pdis. The increase in those parameters may be an indicator for identification of patients at increased risk of atrial fibrillation.

• Authors: Ercan Erdogan, Mehmet Akkaya, Murat Turfan, Gonca Batmaz, Ahmet Bacaksız, Abdurrahman Tasal, Muzaffer Ilhan, Seref Kul, Osman Sönmez, Mehmet Akif Vatankulu, Ertugrul Tasan
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 29 Issue 9 Pg. 830-3 (Sep 2013) ISSN: 1473-0766 [Electronic] England
• PMID: 23855355 (Publication Type: Journal Article, Observational Study)

Topics

• Adult
• Arrhythmias, Cardiac (epidemiology, etiology)
• Body Mass Index
• Case-Control Studies
• Electrocardiography
• Female
• Heart Conduction System (physiopathology)
• Humans
• Polycystic Ovary Syndrome (complications, epidemiology, physiopathology)
• Risk Factors
• Waist Circumference
• Waist-Hip Ratio
• Young Adult