Abstract | OBJECTIVE: Several pathomechanisms are implicated in the pathogenesis of metabolic syndrome (MetS), most of which have not been investigated in African Americans (AAs). We examined the contribution of a selected panel of biomarkers to the development of MetS in Jackson Heart Study (JHS) participants in this investigation. RESEARCH DESIGN AND METHODS: RESULTS: There were 278 (22.9%) of 1,215 participants without MetS at baseline who had development of new-onset MetS at follow-up. The incidence of MetS was significantly associated with serum aldosterone (P=0.004), CRP (P=0.03), and BNP (P for trend=0.005). The multivariable-adjusted odds ratios (95% CI) per SD increment of log biomarker were as follows: 1.25 (1.07-1.45) for aldosterone, 1.20 (1.02-1.43) for CRP, and 1.54 (1.07-2.23) and 1.91 (1.31-2.80) for low and high BNP quartiles, respectively. Aldosterone was positively associated with change in all MetS risk components, except low HDL cholesterol and waist circumference. CRP concentration was significantly and directly associated with change in systolic blood pressure (SBP) and waist circumference but inversely associated with HDL cholesterol. For BNP, we observed a U-shape relation with SBP and triglycerides. CONCLUSIONS: Our analysis confirms that, in AAs, higher circulating aldosterone and CRP concentrations predict incident MetS. The nonlinear U-shape relation of BNP with MetS and its components has not been reported before and thus warrants replication.
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Authors | Solomon K Musani, Ramachandran S Vasan, Aurelian Bidulescu, Jiankang Liu, Vanessa Xanthakis, Mario Sims, Ravi K Gawalapu, Tandaw E Samdarshi, Michael Steffes, Herman A Taylor, Ervin R Fox |
Journal | Diabetes care
(Diabetes Care)
Vol. 36
Issue 10
Pg. 3084-92
(Oct 2013)
ISSN: 1935-5548 [Electronic] United States |
PMID | 23757435
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Natriuretic Peptide, Brain
- Aldosterone
- C-Reactive Protein
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Topics |
- Adult
- Aged
- Aldosterone
(blood)
- C-Reactive Protein
(metabolism)
- Female
- Humans
- Male
- Metabolic Syndrome
(blood)
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
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