The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation.
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| Abstract |
Evidence is accumulating to suggest that our indigenous microbial communities (microbiota) may have a role in modulating allergic and immune disorders of the skin. To examine the link between the microbiota and atopic dermatitis (AD), we examined a mouse model of defective cutaneous barrier function with an AD-like disease due to loss of Notch signaling. Comparisons of conventionally raised and germ-free (GF) mice revealed a similar degree of allergic skin inflammation, systemic atopy, and airway hypersensitivity. GF mutant animals expressed significantly higher levels of thymic stromal lymphopoietin, a major proinflammatory cytokine released by skin with defective barrier function, resulting in a more severe B-lymphoproliferative disorder that persisted into adulthood. These findings suggest a role for the microbiota in ameliorating stress signals released by keratinocytes in response to perturbation in cutaneous barrier function.
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| Authors | Laura J Yockey, Shadmehr Demehri, Mustafa Turkoz, Ahu Turkoz, Philip P Ahern, Omar Jassim, Sindhu Manivasagam, John F Kearney, Jeffrey I Gordon, Raphael Kopan |
| Journal | The Journal of investigative dermatology (J Invest Dermatol) Vol. 133 Issue 12 Pg. 2714-2721 (Dec 2013) ISSN: 1523-1747 [Electronic] United States |
| PMID | 23698100 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
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