Bifidobacterium breve B-3 exerts metabolic syndrome-suppressing effects in the liver of diet-induced obese mice: a DNA microarray analysis.

Abstract

We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.

• Authors: S Kondo, A Kamei, J Z Xiao, K Iwatsuki, K Abe
• Journal: Beneficial microbes (Benef Microbes) Vol. 4 Issue 3 Pg. 247-51 (Sep 2013) ISSN: 1876-2891 [Electronic] Netherlands
• PMID: 23666099 (Publication Type: Journal Article)

Topics

• Animals
• Bifidobacterium (physiology)
• Biological Therapy (methods)
• Diet (methods)
• Disease Models, Animal
• Gene Expression Profiling
• Liver (pathology)
• Metabolic Syndrome (pathology, therapy)
• Mice
• Mice, Obese
• Microarray Analysis
• Obesity (complications)
• Probiotics (administration & dosage)
• Real-Time Polymerase Chain Reaction