A-Form DNA (A-DNA)

An isoform of DNA that occurs in an environment rich in SODIUM and POTASSIUM ions. It is a right-handed helix with 11 base pairs per turn, a pitch of 0.256 nm per base pair and a helical diameter of 2.3 nm.

Also Known As:

Networked: 3516 relevant articles (110 outcomes, 305 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wu, T-C: 14 articles (01/2014 - 05/2003)
2.	Hung, Chien-Fu: 13 articles (01/2014 - 05/2003)
3.	McNeel, Douglas G: 11 articles (08/2015 - 12/2005)
4.	Esteller, Manel: 11 articles (03/2015 - 08/2003)
5.	Jenkins, Mark A: 8 articles (12/2015 - 04/2011)
6.	Lindor, Noralane M: 8 articles (12/2015 - 04/2005)
7.	Win, Aung Ko: 7 articles (12/2015 - 04/2011)
8.	Thibodeau, Stephen N: 7 articles (12/2015 - 04/2005)
9.	D'Andrea, Alan D: 7 articles (04/2015 - 04/2006)
10.	He, Liangmei: 7 articles (01/2013 - 05/2003)

Related Diseases

1.	Infection 01/26/2005 - "These results indicate that a DNA vaccination may be effective against RSV infection even in very young infants and calves." 02/20/2006 - "Both groups of HA-vaccinated ponies were significantly protected from clinical disease following challenge infection, demonstrating the efficacy of rMVA vaccination with or without a DNA prime. " 02/01/2003 - "We have previously shown that mice immunized with a DNA vector expressing p36/LACK of Leishmania infantum followed by a booster with VVp36/LACK induced significant protection against Leishmania major infection. " 09/16/2011 - "These findings demonstrated that a DNA prime-protein boost immunization strategy, but not a DNA vaccine or protein vaccine alone, was effective in eliciting both humoral and cell-mediated immune responses against CVB3 infection in mice and might be a promising vaccine candidate." 07/01/1994 - "A DNA probe (Gen-Probe PACE 2) detects portions of viable and nonviable organisms, and test results could remain positive after effective treatment of genital Neisseria gonorrhoeae infection. "
2.	Neoplasms (Cancer) 01/01/2013 - "We then utilized this ST-expressing tumor cell line to test the efficacy of a DNA vaccine encoding ST. In ST-expressing tumor-bearing mice, this vaccine, pcDNA3-MCC/ST, generated a significant number of ST antigenic peptide-specific CD8+ T cells and experienced markedly enhanced survival compared to mice vaccinated with empty vector. " 10/21/2010 - "Therefore, priming with a DNA vaccine in the presence of α-GalCer and boosting with E7-pulsed DC-1 led to a significant enhancement of E7-specific CD8(+) effector and memory T-cells as well as significantly improved therapeutic and preventive effects against an E7-expressing tumor model (TC-1) in vaccinated mice. " 11/01/2006 - "We show the efficacy of a therapeutic strategy that combines the potency of a DNA-binding photosensitizer, UV(A)Sens, with the tumor-targeting potential of receptor-mediated endocytosis. " 05/15/2011 - "In particular, a novel cycle-amplifying technique using a DNA device on MBs was further employed in the ECL assay of cancer cells, which greatly improved the sensitivity. " 03/01/2013 - "In this report, we evaluated the immune and anti-tumor efficacy of a DNA vaccine targeting the AR LBD (pTVG-AR) in relevant rodent preclinical models. "
3.	Carcinoma (Carcinomatosis) 01/20/2013 - "In 2008, a DNA tumour virus, a polyomavirus (Merkel cell polyomavirus) was detected in Merkel cell carcinomas, and this finding helped to understand the etiological background of the disease. " 11/01/1998 - "Hence, this study shows that there is some relationship between intrinsic radiosensitivity and expression of a DNA repair enzyme in cervical carcinomas. " 11/01/1989 - "A morphometrical assessment of nuclear features and a DNA study were performed on prostate tissue specimens from 33 patients with prostate carcinoma using an image analysing computer. " 12/01/2013 - "The excision repair cross-complementation 1 (ERCC1) is a DNA repair gene coding 5' endonuclease in nucleotide excision repair and is overexpressed in chemo- or radioresistant carcinomas. " 06/01/2013 - "However, a DNA microarray experiment showed that many genes including Notch1 and Cdk1, which are known to be enhanced in ovarian carcinoma, are also increased in the ovaries of Selenbp1 (-/-) mice. "
4.	Tuberculosis (Tuberculoses) 01/01/2011 - "Immunogenicity and protective efficacy against murine tuberculosis of a prime-boost regimen with BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein." 02/01/2001 - "Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis." 06/01/2014 - "tuberculosis clinical isolates within 6 h using only simple instruments, such as a thermal cycler, a hybridization oven, and a DNA chip scanner, and less technician skill was required than for other techniques. " 03/01/2014 - "tuberculosis mutT gene, a homologue of a DNA repair protein in Escherichia coli. " 05/01/2013 - "tuberculosis and treated with a DNA vaccine in an immunotherapeutic regimen. "
5.	Vaccinia 08/01/2004 - "The immunogenicity and protective efficacy of a DNA and recombinant modified vaccinia Ankara (MVA) vaccine administered by two different routes were investigated. " 04/12/2007 - "Dose-response studies for the elicitation of CD8 T cells by a DNA vaccine, used alone or as the prime for a modified vaccinia Ankara boost." 01/01/2015 - "DCs targeted with a DNA vaccine encoding the immunodominant vaccinia B8R gene via RVG-P were able to restimulate vaccinia-specific memory T cells in vitro. " 01/01/2011 - "The immunogenicity of rLSDV-grttn was tested in homologous prime-boost regimens as well as heterologous prime-boost regimes in combination with a DNA vaccine (pVRC-grttn) or modified vaccinia Ankara vaccine (rMVA-grttn) both expressing Grttn. " 02/01/2009 - "Broad, high-magnitude and multifunctional CD4+ and CD8+ T-cell responses elicited by a DNA and modified vaccinia Ankara vaccine containing human immunodeficiency virus type 1 subtype C genes in baboons."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Antigens
3.	Cisplatin (Platino)
4.	Hemagglutinins (Hemagglutinin)
5.	Transcription Factors (Transcription Factor)
6.	DNA Vaccines
7.	Nucleoproteins
8.	Azacitidine (5 Azacytidine)
9.	Epitopes
10.	Transferases

Related Therapies and Procedures

1.	Immunotherapy
2.	Microspheres (Microsphere)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Aftercare (After-Treatment)
5.	Intramuscular Injections