Preclinical models of Parkinson's disease.

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder in which pigmented midbrain neurons progressively die producing a dopamine (DA) deficit in the striatum, which manifests as an akinetic movement disorder. Experimentally induced striatal DA depletion in animals is a valid model of parkinsonism. The capacity of certain substances to damage catecholaminergic neurons has been used extensively to produce DA deficiency in animals. This unit describes methods for inducing parkinsonism in nonhuman primates and rodents using the neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA). Additionally, procedures for evaluating the animals are presented.

• Authors: Krys S Bankiewicz, Rosario Sanchez-Pernaute, Yoshitsugu Oiwa, Malgorzata Kohutnicka, Alex Cummins, Jamie Eberling
• Journal: Current protocols in toxicology (Curr Protoc Toxicol) Vol. Chapter 1 Pg. Unit1.8 (Feb 2004) ISSN: 1934-9262 [Electronic] United States
• PMID: 23045097 (Publication Type: Journal Article)

Chemical References

• Levodopa

Topics

• Animals
• Disease Models, Animal
• Levodopa (administration & dosage)
• MPTP Poisoning
• Macaca fascicularis
• Macaca mulatta
• Mice
• Mice, Inbred C57BL
• Motor Activity
• Parkinson Disease (physiopathology)
• Rats
• Rats, Sprague-Dawley