Abstract | INTRODUCTION: PATIENTS AND METHODS: Between 01/08 and 12/11, 203 patients with symptomatic haemorrhoids were enrolled in the study and received (103 patients) or not (100 patients) 0.4 % GTN ointment for 6 weeks after surgery. Pain was assessed using a 10-cm linear visual analogue scale (VAS). Data on post-operative pain, wound secretion and bleeding, return to normal activities and complications were recorded. Data were analysed using Fisher's exact and Mann-Whitney tests. RESULTS: GTN-treated group experienced significantly less pain during the first week after surgery (p < 0.0001). This difference was more evident starting from post-operative day 4 (p < 0.0001). A significant higher percentage of untreated patients experienced severe pain (mean VAS score > 7) (10 % vs 31 %). There were significant differences in terms of secretion time (p = 0.0052) and bleeding time (p = 0.02) in favor of GTN. In addition, the duration of itching was less in the GTN group (p = 0.0145). Patients treated with GTN were able to an early return to daily activities compared to untreated (p < 0.0001). Fifteen GTN-treated patients (14.6 %) discontinued the application because of local discomfort and headache. CONCLUSIONS: GTN ointment enhances significantly post-operative recovery, reducing pain in terms of duration and intensity. This effect might be secondary to a faster wound healing expressed by reduced secretion, bleeding and itching time.
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Authors | Luana Franceschilli, Stefano D'Ugo, Elisabetta de Luca, Federica Cadeddu, Giovanni Milito, Nicola di Lorenzo, Achille L Gaspari, Pierpaolo Sileri |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 28
Issue 3
Pg. 365-9
(Mar 2013)
ISSN: 1432-1262 [Electronic] Germany |
PMID | 22864620
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aged
- Demography
- Female
- Hemorrhoidectomy
(adverse effects)
- Hemorrhoids
(drug therapy, surgery)
- Humans
- Male
- Middle Aged
- Nitroglycerin
(adverse effects, pharmacology, therapeutic use)
- Ointments
(adverse effects, pharmacology, therapeutic use)
- Pain, Postoperative
(etiology)
- Postoperative Care
- Prospective Studies
- Treatment Outcome
- Wound Healing
(drug effects)
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