Abstract | BACKGROUND: METHODS: RESULTS: Whisker pad mechanical hypersensitivity began in week 2 in wild type rats (3.11 ± 5.93 g vs. 18.72 ± 0.00 g after sham surgery, n = 9, P < 0.001), indicating trigeminal neuropathic pain, but was not evident in transgenic rats (odds ratio: 1.12, 95% confidence interval: 0.38-3.35). Initiation of statistically significant mechanohypersensitivity was delayed until week 6 after surgery in transgenic rats (3.44 ± 4.60 g vs. 18.72 ± 0.00 g, n = 4, P < 0.001). Mechanical allodynia, which persisted 8 weeks in wild type rats was alleviated by Lapatinib (15 ± 3.89 g vs. 2.45 ± 1.13 g, n = 6, P < 0.001). Infraorbital nerve damage was verified histologically. Statistically significant ErbB3 increases (weeks 5 and 10) in wild type and transgenic rats (week 10) coincided with time points when mechanical hypersensitivity was present. CONCLUSION: The Neuregulin 1-ErbB3-ErbB2 complex is a causal mechanism in nerve injury-induced trigeminal neuropathic pain. Understanding peripheral glial mechanisms after nerve injury will improve neuropathic pain treatment.
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Authors | Fei Ma, Liping Zhang, Karin N Westlund |
Journal | Anesthesiology
(Anesthesiology)
Vol. 117
Issue 2
Pg. 381-8
(Aug 2012)
ISSN: 1528-1175 [Electronic] United States |
PMID | 22705569
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Protein Kinase Inhibitors
- Quinazolines
- Lapatinib
- Receptor, ErbB-2
- Receptor, ErbB-3
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Topics |
- Animals
- Blotting, Western
- Disease Models, Animal
- Hyperalgesia
(physiopathology)
- Lapatinib
- Male
- Neuralgia
(physiopathology)
- Pain Threshold
- Protein Kinase Inhibitors
(administration & dosage)
- Quinazolines
(administration & dosage)
- Rats
- Rats, Inbred F344
- Receptor, ErbB-2
- Receptor, ErbB-3
- Trigeminal Nerve Injuries
(physiopathology)
- Vibrissae
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