Abstract | INTRODUCTION: METHODS: Detailed clinical data and sera from 963 patients with SSc enrolled in a multicenter cohort study were collected and entered into a central database. Antibodies to Ro52/TRIM21 and other autoantibodies were detected with an addressable laser-bead immunoassay and different enzyme-linked immunosorbent assay (ELISA) systems. Associations between anti-Ro52/TRIM21 antibodies and clinical and other serologic manifestations of SSc were investigated. RESULTS: CONCLUSIONS:
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Authors | Marie Hudson, Janet Pope, Michael Mahler, Solène Tatibouet, Russell Steele, Murray Baron, Canadian Scleroderma Research Group (CSRG), Marvin J Fritzler |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 14
Issue 2
Pg. R50
(Mar 06 2012)
ISSN: 1478-6362 [Electronic] England |
PMID | 22394602
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Biomarkers
- Ribonucleoproteins
- SS-A antigen
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Topics |
- Adult
- Aged
- Autoantibodies
(biosynthesis, blood)
- Biomarkers
(blood)
- Cohort Studies
- Cross-Sectional Studies
- Female
- Humans
- Male
- Middle Aged
- Ribonucleoproteins
(immunology)
- Scleroderma, Systemic
(diagnosis, immunology, metabolism)
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