RNA Polymerase III

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure where it transcribes DNA into RNA. It has specific requirements for cations and salt and has shown an intermediate sensitivity to alpha-amanitin in comparison to RNA polymerase I and II. EC 2.7.7.6.

Also Known As:

Networked: 159 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shah, Ami A: 5 articles (11/2015 - 09/2010)
2.	Levy, Daniel: 5 articles (02/2015 - 01/2013)
3.	Zhong, Qian: 5 articles (02/2015 - 01/2013)
4.	Zhong, Shuping: 5 articles (02/2015 - 01/2013)
5.	Shi, Ganggang: 4 articles (02/2015 - 08/2013)
6.	Ceribelli, Angela: 4 articles (07/2011 - 06/2009)
7.	Casciola-Rosen, Livia: 3 articles (11/2015 - 09/2010)
8.	Rosen, Antony: 3 articles (04/2015 - 09/2010)
9.	Kuwana, Masataka: 3 articles (04/2015 - 10/2002)
10.	Zhang, Yanmei: 3 articles (02/2015 - 08/2013)

Related Diseases

1.	Systemic Scleroderma (Systemic Sclerosis) 05/01/2015 - "Association of anti-RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis." 02/01/2015 - "Anti-RNA polymerase III antibody (RNAP) is primarily detected in diffuse cutaneous type systemic sclerosis (dcSSc) patients and strongly associated with renal crisis. " 01/01/2010 - "Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study." 10/01/2009 - "A longitudinal study of anti-RNA polymerase III antibody levels in systemic sclerosis." 06/01/2009 - "Increased apoptosis in circulating lymphocyte cultures of anti-RNA polymerase III positive patients with systemic sclerosis."
2.	Neoplasms (Cancer) 08/14/2015 - "Maf1 was first identified in yeast, and studies in metazoans have primarily focused on examining its role in the repression of transcription that is dependent on RNA polymerase III. Recent work has revealed a novel and conserved function for Maf1 in the maintenance of intracellular lipid pools in Caenorhabditis elegans, mice, and cancer cell lines. " 04/01/2015 - "In the adjusted model 2, only anti-RNA polymerase III positivity (odds ratio 5.08 [95% confidence interval 1.60-16.1]) and older age at scleroderma onset (odds ratio 1.04 [95% confidence interval 1.00-1.08]) were significantly associated with a short cancer-scleroderma interval. " 02/01/2013 - "Here, we report that INMAP might be conserved from prokaryotes to humans, is a truncated version of the RNA polymerase III subunit B POLR3B, and is up-regulated in several human cancer cell lines including HeLa, Bel-7402, HepG2 and BGC-823. " 11/01/2011 - "A unique nucleolar RNA polymerase III expression pattern has been identified in malignant tissue from these scleroderma patients suggesting that autoantigen expression in the cancer and the autoantibody response are associated. " 01/01/2011 - "RNA polymerase III transcription in cancer: the BRF2 connection."
3.	Infection 03/11/2015 - "The human genome contains about 1.5 million Alu elements, which are transcribed into Alu RNAs by RNA polymerase III. Their expression is upregulated following stress and viral infection, and they associate with the SRP9/14 protein dimer in the cytoplasm forming Alu RNPs. " 06/01/1993 - "We found that transcription of endogenous human Alu elements by RNA polymerase III was strongly stimulated following infection of HeLa cells with adenovirus type 5, leading to the accumulation of high levels of Alu transcripts initiated from Alu polymerase III promoters. " 06/15/1992 - "Infection with herpes simplex virus (HSV) results in an increase in the transcription of the endogenous Alu repeated sequence by RNA polymerase III. This effect is also observed in uninfected cells stably transformed with a plasmid expressing the HSV immediate-early protein ICP27 or in cells transfected with the gene encoding this protein. " 12/04/1989 - "HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III." 11/01/1987 - "Experiments utilizing two different cell lines showed that the initiation step of transcription by RNA polymerase III was impaired by infection of these cells with the virus. "
4.	Shock 11/01/1992 - "B2 genes are short, repetitive sequences whose transcription (by RNA polymerase III) are also increased after heat shock. " 07/25/1986 - "Induction of B2 RNA polymerase III transcription by heat shock: enrichment for heat shock induced sequences in rodent cells by hybridization subtraction." 07/25/1986 - "Transcription of B2 RNA by RNA polymerase III was rapidly induced after heat shock based on time course studies and nuclear runoff experiments. " 05/01/1996 - "It was supposed that 5.3S RNA is transcribed by RNA polymerase III and involved in protein synthesis regulation in plant cells under heat shock conditions at the level of translation initiation." 11/01/1992 - "The data indicate that auto-regulation of the level of mouse heat shock gene products is mediated by RNA polymerase II transcripts but that the regulatory mechanism can control transcription from RNA polymerase III genes as well."
5.	Leukemia 11/01/1995 - "Studies with polymerase inhibitors suggest that this LTR transcript, designated let (LTR-encoded trans activator), is a product of RNA polymerase III. The mechanisms whereby RNA leukemia viruses cause lymphoid neoplasia after a long latent period have been extensively studied but are only partially understood. " 09/01/2001 - "To overcome P-gp-mediated drug resistance, we have developed six anti-MDR1 hammerhead ribozymes and delivered them to P-gp-overproducing human leukemia cell line by a retroviral vector containing RNA polymerase III promoter. " 02/05/2013 - "Here, using deep sequencing of broad windows of small RNA sizes in the bovine leukemia virus ovine model of leukemia/lymphoma, we provide in vivo evidence of the production of noncanonical RNA polymerase III (Pol III)-transcribed viral microRNAs in leukemic B cells in the complete absence of Pol II 5'-LTR-driven transcriptional activity. "

Related Drugs and Biologics

1.	Antibodies
2.	RNA (Ribonucleic Acid)
3.	DNA (Deoxyribonucleic Acid)
4.	transcription factor TFIIIC
5.	Trans-Activators (Trans-Acting Factor)
6.	Autoantibodies
7.	DNA Polymerase III (Pol III)
8.	RNA Polymerase II (RNA Polymerase B)
9.	Type I DNA Topoisomerases (Topoisomerase I)
10.	Messenger RNA (mRNA)