Abstract | OBJECTIVES: METHODS: From 2003 to 2008, 155 myeloma patients were examined to determine their chronic hepatitis virus infection statuses using serologic tests for the hepatitis B (HBV) and C viruses (HCV). Clinical parameters and outcome variables were retrieved via a medical chart review. RESULTS: The estimated prevalences of chronic HBV and HCV infections were 11.0% (n = 17) and 9.0% (n = 14), respectively. The characteristics of patients who were hepatitis virus carriers and those who were not were similar. However, carrier patients had a higher prevalence of conventional cytogenetic abnormalities (64.3% vs. 25.0%). The cumulative incidences of grade 3-4 elevation of the level of alanine transaminase, 30.0% vs. 12.0%, and hyperbilirubinemia, 20.0% vs. 1.6%, were higher in carriers as well. In a Kaplan-Meier analysis, carrier patients had worse overall survival (median: 16.0 vs. 42.4 months). The prognostic value of carrier status was not statistically significant in the multivariate analysis, but an age of more than 65 years old, the presence of cytogenetic abnormalities, a beta-2-microglobulin level of more than 3.5 mg/L, and a serum creatinine level of more than 2 mg/ dL were independent factors associated with poor prognosis. CONCLUSION:
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Authors | Chung-Jen Teng, Han-Tsung Liu, Chun-Yu Liu, Chi-Hsiu Hsih, Jih-Tung Pai, Jyh-Pyng Gau, Jin-Hwang Liu, Tzeon-Jye Chiou, Hui-Chi Hsu, Po-Min Chen, Cheng-Hwai Tzeng, Yuan-Bin Yu |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 66
Issue 12
Pg. 2055-61
( 2011)
ISSN: 1980-5322 [Electronic] United States |
PMID | 22189730
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aspartate Aminotransferases
- Alanine Transaminase
- Bilirubin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alanine Transaminase
(blood)
- Aspartate Aminotransferases
(blood)
- Bilirubin
(blood)
- Carrier State
- Chronic Disease
- Cytogenetic Analysis
- Female
- Hepatitis B, Chronic
(complications, genetics)
- Hepatitis C, Chronic
(complications, genetics)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multiple Myeloma
(complications, genetics)
- Virus Activation
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