N-Acetylcysteine prevents baker's-yeast-induced inflammation and fever.

Abstract

OBJECTIVE AND DESIGN:

To investigate whether N-acetylcysteine (NAC) alters baker's-yeast-induced fever and inflammation.

MATERIAL OR SUBJECTS:

Male Wistar rats (26-28 days old) injected with baker's yeast (135 mg/kg, intraperitoneal) or prostaglandin E(2) (300 ng/100 μL, intrathecal).

TREATMENT:

Rats were injected with NAC (500 mg/kg, subcutaneous, or 50 μg/100 μL, intrathecal) 1 h before, or 2 h after, pyrogen injection.

METHODS:

Rectal temperature changes induced by baker's yeast, PGE(2) and NAC were followed up over time. Four hours after baker's yeast injection, total leukocytes, protein, interleukin (IL)-1β, tumor necrosis factor (TNF)-α and nonprotein thiol content were assessed in peritoneal lavage and hypothalamus.

RESULTS:

Systemic administration of NAC decreased leukocytes, protein, IL-1β and TNF-α levels in peritoneal lavage, and decreased IL-1β levels in the hypothalamus. The central administration of NAC prevented baker's-yeast-induced fever, but did not alter the febrile response elicited by prostaglandin E(2).

CONCLUSION:

These results suggest an anti-inflammatory and antipyretic role for NAC in yeast-induced peritonitis.

• Authors: Ana Paula Oliveira Ferreira, Juliana Saibt Martins Pasin, André Luis Lopes Saraiva, Viviane Ratzlaff, Mateus Fortes Rossato, Rosália Andrighetto, Maribel Antonello Rubin, Juliano Ferreira, Carlos Fernando Mello
• Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 61 Issue 2 Pg. 103-12 (Feb 2012) ISSN: 1420-908X [Electronic] Switzerland
• PMID: 22057902 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antipyretics
• Free Radical Scavengers
• Interleukin-1beta
• Proteins
• Tumor Necrosis Factor-alpha
• Dinoprostone
• Acetylcysteine

Topics

• Acetylcysteine (pharmacology, therapeutic use)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Antipyretics (pharmacology, therapeutic use)
• Dinoprostone (pharmacology)
• Fever (drug therapy, microbiology)
• Free Radical Scavengers (pharmacology)
• Hypothalamus (chemistry, metabolism)
• Interleukin-1beta (analysis)
• Leukocyte Count
• Male
• Peritoneal Lavage
• Peritonitis (drug therapy, metabolism, microbiology)
• Proteins (analysis)
• Rats
• Rats, Wistar
• Saccharomyces cerevisiae (drug effects)
• Tumor Necrosis Factor-alpha (analysis)