Abstract | PURPOSE: Electroconvulsive therapy (ECT) is a psychiatric treatment in which seizures are electrically induced in patients. Prior to treatment, patients are usually given short-acting anaesthetics and muscle relaxants to avoid harm, e.g. musculoskeletal injury, during the convulsions. However, most molecular studies investigating the mechanism of action of ECT have not explored the potential effects of the pre-treatment with anaesthetic and/ or muscle relaxant. EXPERIMENTAL DESIGN: RESULTS: CONCLUSIONS AND CLINICAL RELEVANCE: These findings indicate that caution should be used when interpreting results in existing and future proteome-based biomarkers studies on the effects of ECT in neuropsychiatric disease or the use of anaesthetic/muscle relaxant in major surgical operations related to different therapeutic areas.
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Authors | Viktoria Stelzhammer, Matthias Rothermundt, Paul C Guest, Nikolaus Michael, Carina Sondermann, Wolfgang Kluge, Daniel Martins-de-Souza, Hassan Rahmoune, Sabine Bahn |
Journal | Proteomics. Clinical applications
(Proteomics Clin Appl)
Vol. 5
Issue 11-12
Pg. 644-9
(Dec 2011)
ISSN: 1862-8354 [Electronic] Germany |
PMID | 22006837
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Neuromuscular Depolarizing Agents
- Methohexital
- Succinylcholine
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Topics |
- Anesthesia
(adverse effects)
- Depressive Disorder, Major
(therapy)
- Electroconvulsive Therapy
(methods)
- Female
- Humans
- Male
- Methohexital
(adverse effects)
- Middle Aged
- Neuromuscular Depolarizing Agents
(adverse effects)
- Proteomics
- Succinylcholine
(adverse effects)
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