Abstract | BACKGROUND: PURPOSE: METHODS: Fourty patients with CT- scanning proof of supratentorial tumors were classified equally into 2 groups (twenty patients in each group). Group A:-- Dexmedetomidine was given as a bolus dose of 1 microg/kg in 20 minutes before induction of anesthesia, followed by a maintenance infusion of 0.4 microg/kg/hr. The infusion was discontinued when surgery ended. Group B:--The patients received similar volumes of saline. RESULTS: Heart rate and mean arterial blood pressure, decreased significantly in patients of group A ( dexmedetomidine group) compared to group B (placebo group) (p-value < 0.05). There was no significant statistical difference between the two groups regarding the central venous pressure and arterial partial pressure of carbon dioxide (p-value > 0.05). The intraoperative end-tidal sevoflurane (%) in patients of group A was less than in patients of group B (p-value < 0.05). The intracranial pressure decreased in patients of Group A more than group B (p-value < 0.05). The Glasgow coma scale (GCS) improved in patients of group A and deteriorated in patients of Group B with significant statistical difference between the two groups (p-value < 0.05). The total fentanyl requirements from induction to extubation of patients increased in patients of group B more than in patients of group A (p-value < 0.05). The total postoperative patients' requirements for antiemetic drugs within the 2 hours after extubation decreased in patients of group A more than group B (p-value < 0.05). The postoperative duration from the end of surgery to extubation decreased significantly in patients of group A more than group B (p-value < 0.05). The total urine output during the duration from drug administration to extubation of patients increased in patients of group A more than group B (p-value < 0.05). CONCLUSION:
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Authors | Rabie Nasr Soliman, Amira Refaie Hassan, Amr Madih Rashwan, Ahmed Mohamed Omar |
Journal | Middle East journal of anaesthesiology
(Middle East J Anaesthesiol)
Vol. 21
Issue 1
Pg. 23-33
(Feb 2011)
ISSN: 0544-0440 [Print] Lebanon |
PMID | 21991729
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Dexmedetomidine
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Topics |
- Adult
- Aged
- Analgesics, Non-Narcotic
(therapeutic use)
- Anesthesia, General
- Blood Pressure
- Craniotomy
- Dexmedetomidine
(therapeutic use)
- Double-Blind Method
- Female
- Heart Rate
- Humans
- Male
- Middle Aged
- Prospective Studies
- Supratentorial Neoplasms
(physiopathology, surgery)
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