Adrenergic Receptors (Adrenergic Receptor)

Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.

Also Known As:

Networked: 3359 relevant articles (101 outcomes, 349 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Koch, Walter J: 32 articles (11/2014 - 01/2002)
2.	Rengo, Giuseppe: 12 articles (01/2014 - 03/2007)
3.	Rockman, Howard A: 11 articles (09/2007 - 07/2003)
4.	Naga Prasad, Sathyamangla V: 10 articles (01/2015 - 07/2003)
5.	Eckhart, Andrea D: 10 articles (01/2011 - 01/2002)
6.	Koch, W J: 9 articles (10/2011 - 05/2000)
7.	Perrino, Cinzia: 9 articles (03/2010 - 07/2003)
8.	Leosco, Dario: 8 articles (01/2014 - 12/2009)
9.	Liggett, Stephen B: 8 articles (08/2013 - 11/2003)
10.	Bristow, Michael R: 7 articles (04/2015 - 05/2002)

Related Diseases

1.	Heart Failure 12/04/2001 - "beta-Adrenergic receptor blockade is one of the most effective treatments for heart failure, a leading cause of mortality worldwide. " 01/01/2007 - "Beta-adrenergic receptor activation plays an important role in the progression of human heart failure and the treatment of patients with beta-blockers has greatly improved the outcome of the disease. " 12/09/2003 - "Although beta-adrenergic receptor (AR) blockade therapy is beneficial in the treatment of heart failure, little is known regarding the transcriptional mechanisms underlying this salutary action. " 06/17/1999 - "Whether or not stimulation or inhibition of the beta-adrenergic receptor signaling pathway is beneficial in heart failure is controversial. " 08/01/2004 - "beta-adrenergic receptor (betaAR) antagonists, or beta blockers, are now a part of the standard therapeutic arsenal in the medical management of chronic heart failure (HF). "
2.	Hypertension (High Blood Pressure) 10/01/2010 - "To test the hypothesis that nonselective blockade of adrenergic receptor (AR) subtypes is superior to selective blockade of AR subtypes in suppressing left ventricular (LV) remodeling induced by hypertension. " 03/01/2010 - "The adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic association studies (GAS) are controversial and inconclusive. " 03/01/2010 - "Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database." 08/01/2004 - "In the present study, we tested regulation of cardiac I(1)-receptors versus alpha(2) -adrenoceptors in response to hypertension and to chronic exposure to agonist. " 07/01/2003 - "The aims of this study was to characterize the functional response of atypical beta-adrenoceptors (beta-AR) in rat aorta and to investigate whether this relaxation was altered before and during the development of hypertension. "
3.	Bradycardia 04/01/1994 - "Administration of an alpha-adrenergic receptor antagonist eliminated the pressor response and bradycardiac response produced by area 25 stimulation but it had no effect on the bradycardia elicited by stimulation of area 24 or area 32. " 04/01/1997 - "Muscarinic and beta-adrenergic receptor blockade studies in anesthetized dogs demonstrated the bradycardia to be due to withdrawal of cardiac sympathetic tone. " 12/01/2012 - "We hypothesize that the disruption of M(2) MR, key players in parasympathetic bradycardia, would change the number of receptors with antagonistic effects on the heart (β(1)- and β(2)-adrenoceptors, BAR), while the function of the heart would be changed only marginally. " 07/01/2005 - "The effect of the autonomic nervous system in causing training-induced resting bradycardia and in restoring heart rate (HR) to pre-exercise training level (PET) with detraining was examined indirectly after cardiac muscarinic and adrenergic receptor blockade. " 12/01/2004 - "The effect of the autonomic nervous system in generating training-induced resting bradycardia (RB) was examined indirectly after cardiac muscarinic and adrenergic receptor blockade. "
4.	Hypertrophy 01/27/2015 - "Carabin also conferred protection against adrenergic receptor-induced hypertrophy in isolated cardiomyocytes. " 03/01/2008 - "1. With the generation of gene knockout (KO) or transgenic overexpression (TG) mouse models targeting adrenoceptors (AR), recent studies in vivo have investigated the role of AR subtypes in pressure overload-induced left ventricular (LV) hypertrophy and remodelling. " 10/01/1998 - "Nevertheless, in clinical studies as well as animal models,beta-adrenergic receptor mediated augmentation of L-type Ca2+ currents has been demonstrated to be reduced, in general, with hypertrophy and CHF. " 01/01/1983 - "4. Divergent results of studies on beta-adrenoceptors in ventricular hypertrophy are difficult to reconcile." 01/01/2015 - "In particular, we uncover the existence of a phosphodiesterase-dependent receptor-microdomain communication, which is affected in hypertrophy, resulting in reduced β-adrenergic receptor-cAMP signalling to SERCA. "
5.	Neoplasms (Cancer) 07/01/2010 - "Many recent studies have focused on the function of β-adrenoceptors in cancer invasion. " 01/01/2015 - "Thus, we hypothesized that the cancer-promoting effect of NNK was likely mediated through beta-adrenoceptors in ESCC. " 09/01/2014 - "It is established that there is activation of 2 well-known stress axes under stress, the hypothalamic-pituitary-adrenal axis and sympatho-adrenal-medullary axis, where especially the proliferating promoting effects on the malignant tumor events are known to depend on β-adrenergic receptors. " 07/11/2014 - "Because the deubiquitinating enzyme USP33 is involved in several important cellular processes (β-adrenergic receptor recycling, centrosome amplification, RalB signaling, and cancer cell migration), its levels must be carefully regulated. " 12/01/2013 - "The results also suggest that SNS activation may regulate tumor progression through alterations in the extracellular matrix, with outcome dependent on the combination of adrenergic receptor activated. "

Related Drugs and Biologics

1.	Propranolol (Inderal)
2.	Phentolamine (Z-Max)
3.	carvedilol (Coreg)
4.	Norepinephrine (Noradrenaline)
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6.	Isoproterenol (Isoprenaline)
7.	Atropine (Hyoscyamine)
8.	Prazosin (Minipress)
9.	Epinephrine (Adrenaline)
10.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Adrenalectomy
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Aftercare (After-Treatment)
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)