Abstract | BACKGROUND: METHODS: We examined the association between N(ε)-( carboxymethyl)lysine (CML), a prominent AGE, and sRAGE and colorectal cancer risk in a prospective case-cohort study nested within a cancer prevention trial among 29,133 Finnish male smokers. Among study subjects who were alive without cancer 5 years after baseline (1985-1988), we identified 483 incident colorectal cancer cases and randomly sampled 485 subcohort participants as the comparison group with the follow-up to April 2006. Baseline serum levels of CML-AGE, sRAGE, glucose and insulin were determined. Weighted Cox proportional hazard regression models were used to calculate relative risks (RR) and 95% CI. RESULTS: Comparing highest with lowest quintile of sRAGE, the RR for incident colorectal cancer was 0.65 (95% CI, 0.39-1.07; P(trend) = 0.03), adjusting for age, years of smoking, body mass index, and CML-AGE. Further adjustment for serum glucose strengthened the association (RR = 0.52; 95% CI, 0.30-0.89; P(trend) = 0.009). Highest quintile of CML-AGE was not associated with an increased risk of colorectal cancer (multivariate RR = 1.20; 95% CI, 0.64-2.26). CONCLUSIONS: Higher prediagnostic levels of serum sRAGE were associated with lower risk of colorectal cancer in male smokers. IMPACT: This is the first epidemiologic study to implicate the receptor for AGEs in colorectal cancer development.
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Authors | Li Jiao, Philip R Taylor, Stephanie J Weinstein, Barry I Graubard, Jarmo Virtamo, Demetrius Albanes, Rachael Z Stolzenberg-Solomon |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 20
Issue 7
Pg. 1430-8
(Jul 2011)
ISSN: 1538-7755 [Electronic] United States |
PMID | 21527578
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
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Copyright | ©2011 AACR |
Chemical References |
- Biomarkers, Tumor
- Blood Glucose
- Glycation End Products, Advanced
- Insulin
- Receptor for Advanced Glycation End Products
- Receptors, Immunologic
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Topics |
- Aged
- Biomarkers, Tumor
(analysis, blood)
- Blood Glucose
- Case-Control Studies
- Cohort Studies
- Colorectal Neoplasms
(blood, epidemiology)
- Enzyme-Linked Immunosorbent Assay
- Finland
- Glycation End Products, Advanced
(blood)
- Humans
- Insulin
(blood)
- Male
- Middle Aged
- Proportional Hazards Models
- Receptor for Advanced Glycation End Products
- Receptors, Immunologic
(blood)
- Risk Factors
- Smoking
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