Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy.

Abstract

BACKGROUND:

Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored.

METHODS:

Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort.

RESULTS:

There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women.

CONCLUSION:

Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.

• Authors: Adetunji T Toriola, Helja-Marja Surcel, Anika Husing, Kjell Grankvist, Hans-Ake Lakso, Helena Schock, Eva Lundin, Matti Lehtinen, Annekatrin Lukanova
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 22 Issue 6 Pg. 925-8 (Jun 2011) ISSN: 1573-7225 [Electronic] Netherlands
• PMID: 21387179 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Gonadal Steroid Hormones
• Vitamin D
• Insulin-Like Growth Factor I
• 25-hydroxyvitamin D

Topics

• Adolescent
• Adult
• Cohort Studies
• Female
• Gonadal Steroid Hormones (blood)
• Humans
• Insulin-Like Growth Factor I (analysis, metabolism)
• Mothers
• Osmolar Concentration
• Pregnancy (blood, metabolism)
• Pregnancy Trimester, First (blood, metabolism)
• Vitamin D (analogs & derivatives, blood)
• Young Adult