Reduced antioxidant defense in early onset first-episode psychosis: a case-control study.

Abstract

BACKGROUND:

Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.

METHODS:

Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.

RESULTS:

A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.

CONCLUSIONS:

Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.

• Authors: Juan Antonio Micó, Maria Olga Rojas-Corrales, Juan Gibert-Rahola, Mara Parellada, Dolores Moreno, David Fraguas, Montserrat Graell, Javier Gil, Jon Irazusta, Josefina Castro-Fornieles, Cesar Soutullo, Celso Arango, Soraya Otero, Ana Navarro, Inmaculada Baeza, Mónica Martínez-Cengotitabengoa, Ana González-Pinto
• Journal: BMC psychiatry (BMC Psychiatry) Vol. 11 Pg. 26 (Feb 14 2011) ISSN: 1471-244X [Electronic] England
• PMID: 21320302 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Reactive Oxygen Species
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione

Topics

• Adolescent
• Age of Onset
• Antioxidants (metabolism, physiology)
• Case-Control Studies
• Catalase (blood, metabolism)
• Child
• Diagnostic and Statistical Manual of Mental Disorders
• Erythrocytes (enzymology, metabolism)
• Female
• Glutathione (blood, deficiency, metabolism)
• Glutathione Peroxidase (blood, metabolism)
• Humans
• Lipid Peroxidation (physiology)
• Male
• Oxidative Stress (physiology)
• Psychotic Disorders (blood, metabolism, physiopathology)
• Reactive Oxygen Species (metabolism)
• Schizophrenia (blood, metabolism, physiopathology)
• Superoxide Dismutase (blood, metabolism)