Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Recent publications support a role of ghrelin in modulating glucose homeostasis. Novel cellular mechanisms have been proposed to explain these effects. Controversy on this topic continues to exist owing to inconsistent observations made in both rodents and humans. Many recent studies are uncovering a role of des-acyl ghrelin in glucose metabolism specifically in modulating insulin sensitivity and glucose uptake into adipocytes. A novel role of ghrelin acylation by the enzyme GOAT in regulating glucose metabolism during caloric deprivation has newly been discovered. SUMMARY:
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Authors | Kristy M Heppner, Jenny Tong, Henriette Kirchner, Ralf Nass, Matthias H Tschöp |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 18
Issue 1
Pg. 50-5
(Feb 2011)
ISSN: 1752-2978 [Electronic] England |
PMID | 21150588
(Publication Type: Journal Article, Review)
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Chemical References |
- Ghrelin
- Insulin
- Acyltransferases
- MBOAT4 protein, human
- Glucose
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Topics |
- Acyltransferases
(genetics, metabolism, physiology)
- Animals
- Diabetes Mellitus, Type 2
(genetics, therapy)
- Energy Metabolism
(genetics)
- Ghrelin
(metabolism, physiology)
- Glucose
(metabolism)
- Growth and Development
(physiology)
- Humans
- Insulin
(metabolism)
- Insulin Secretion
- Signal Transduction
(physiology)
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