Brain-derived neurotrophic factor and neuron-specific enolase, but not S100β, levels are associated to the occurrence of delirium in intensive care unit patients.

Abstract

PURPOSE:

The aim of this study was to determine the association between serum concentrations of brain-derived neurotrophic factor (BDNF), neuron-specific enolase (NSE), and S100β and the occurrence of delirium in critically ill patients.

MATERIAL AND METHODS:

This case-control study included 30 patients with delirium and 30 matched controls in a 16-bed general intensive care unit (ICU). Serum BDNF, NSE, and S100 concentrations were determined by enzyme-linked immunosorbent assay assays at the time of ICU admission and on the day before delirium was diagnosed. Delirium was diagnosed by confusion assessment method for the ICU.

RESULTS:

At ICU admission, serum BDNF levels were significantly higher in delirious patients than in nondelirious controls (2.89 ± 1.48 vs 1.79 ± 0.89 ng/mL, respectively). When we compared serum S100 levels, there were no significant differences between the groups. Neuron-specific enolase values were significantly higher in the delirious patients than in the nondelirious controls (0.79 ± 0.03 ng/mL vs 0.59 ± 0.01 ng/mL, respectively). When patients who earlier developed delirium were separately analyzed, it was determined that serum NSE and BDNF levels at admission were significant higher only in this group.

CONCLUSIONS:

Our results suggest that admission serum BDNF and NSE levels are associated with the occurrence of delirium in ICU patients.

• Authors: Carmen Grandi, Cristiane Damiani Tomasi, Keiti Fernandes, Laura Stertz, Flávio Kapczinski, João Quevedo, Felipe Dal-Pizzol, Cristiane Ritter
• Journal: Journal of critical care (J Crit Care) Vol. 26 Issue 2 Pg. 133-7 (Apr 2011) ISSN: 1557-8615 [Electronic] United States
• PMID: 21106342 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Brain-Derived Neurotrophic Factor
• Nerve Growth Factors
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins
• Phosphopyruvate Hydratase

Topics

• Adult
• Aged
• Biomarkers (blood)
• Brain-Derived Neurotrophic Factor (blood)
• Case-Control Studies
• Critical Illness
• Delirium (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Intensive Care Units
• Male
• Middle Aged
• Nerve Growth Factors (blood)
• Phosphopyruvate Hydratase (blood)
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins (blood)