Abstract | BACKGROUND: Exposure-response information about particulate air-pollution constituents is needed to protect sensitive populations. Particulate matter <2.5 mm (PM2.5) components may induce oxidative stress through reactive-oxygen-species generation, including primary organics from combustion sources and secondary organics from photochemically oxidized volatile organic compounds. We evaluated differences in airway versus systemic inflammatory responses to primary versus secondary organic particle components, particle size fractions, and the potential of particles to induce cellular production of reactive oxygen species. METHODS: RESULTS: Secondary organic markers, PM0.25-2.5, and O3 were positively associated with exhaled NO. Primary organic markers, PM0.25, CO, and NOx were positively associated with IL-6. Reactive oxygen species were associated with both outcomes. CONCLUSIONS: Particle effects on airway versus systemic inflammation differ by composition, but overall particle potential to induce generation of cellular reactive oxygen species is related to both outcomes.
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Authors | Ralph J Delfino, Norbert Staimer, Thomas Tjoa, Mohammad Arhami, Andrea Polidori, Daniel L Gillen, Steven C George, Martin M Shafer, James J Schauer, Constantinos Sioutas |
Journal | Epidemiology (Cambridge, Mass.)
(Epidemiology)
Vol. 21
Issue 6
Pg. 892-902
(Nov 2010)
ISSN: 1531-5487 [Electronic] United States |
PMID | 20811287
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Aerosols
- Air Pollutants
- Organic Chemicals
- Reactive Oxygen Species
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Topics |
- Aerosols
- Aged
- Aged, 80 and over
- Air Pollutants
(toxicity)
- Bronchi
(drug effects, metabolism, pathology)
- Cohort Studies
- Female
- Humans
- Inflammation
(chemically induced)
- Longitudinal Studies
- Male
- Organic Chemicals
(toxicity)
- Reactive Oxygen Species
(metabolism)
- Systemic Inflammatory Response Syndrome
(chemically induced)
- Trachea
(drug effects, metabolism, pathology)
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