Abstract | INTRODUCTION:
Aneurysmal subarachnoid hemorrhage (SAH) affects relatively young people and carries a poor prognosis with a case fatality rate of 35%. One of the major systemic complications associated with SAH is acute lung injury (ALI) which occurs in up to one-third of the patients and is associated with poor outcome. ALI in SAH may be predisposed by neurogenic pulmonary edema (NPE) and inflammatory mediators. The objective of this study was to assess the immunomodulatory effects of interferon-β (IFN-β) on inflammatory mediators in the lung after experimental SAH. METHODS: Male Wistar rats were subjected to the induction of SAH by means of the endovascular filament method. Sham-animals underwent sham-surgery. Rats received IFN-β for four consecutive days starting at two hours after SAH induction. After seven days, lungs were analyzed for the expression of inflammatory markers. RESULTS: CONCLUSIONS:
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Authors | Pieter M Cobelens, Ivo A C W Tiebosch, Rick M Dijkhuizen, Peter H van der Meide, René Zwartbol, Cobi J Heijnen, Jozef Kesecioglu, Walter M van den Bergh |
Journal | Critical care (London, England)
(Crit Care)
Vol. 14
Issue 4
Pg. R157
( 2010)
ISSN: 1466-609X [Electronic] England |
PMID | 20731855
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokine CCL3
- Chemokine CXCL1
- Cxcl1 protein, rat
- E-Selectin
- Tumor Necrosis Factor-alpha
- Vascular Cell Adhesion Molecule-1
- Intercellular Adhesion Molecule-1
- Interferon-beta
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Topics |
- Acute Lung Injury
(drug therapy, etiology)
- Animals
- Chemokine CCL3
(analysis)
- Chemokine CXCL1
(analysis)
- E-Selectin
(analysis)
- Inflammation
(drug therapy)
- Intercellular Adhesion Molecule-1
(analysis)
- Interferon-beta
(therapeutic use)
- Lung
(chemistry, drug effects, pathology)
- Male
- Neutrophil Infiltration
(drug effects)
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
- Subarachnoid Hemorrhage
(complications, drug therapy)
- Tumor Necrosis Factor-alpha
(analysis)
- Vascular Cell Adhesion Molecule-1
(analysis)
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