Abstract | PURPOSE: METHODS: RESULTS: Serum levels of all proteins tested were significantly higher in CRC patients than in healthy subjects. Additionally, serum TIMP-1 was significantly higher in patients with CRC than in CA patients. Concentrations of TIMP-1 correlated with tumor stage, nodal involvement, presence of distant metastases, patients' survival, and tumor resectability. Diagnostic sensitivity of TIMP-1 was higher (61%) than those of other biomarkers ( MMP-9, 55%; CEA, 39%; CA 19-9, 11%), and increased in combined use with MMP-9 (75%) or CEA (73%). The areas under receiver operating characteristic curves of TIMP-1 were larger than those of MMP-9. CONCLUSIONS: Our findings suggest better usefulness of serum TIMP-1 than MMP-9 in the diagnosis of CRC, especially in the assessment of Duke's classification of tumor stage, survival of cancer patients, resectability of tumor, and in the differentiation between CA and cancer.
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Authors | Barbara Mroczko, Magdalena Groblewska, Bogna Okulczyk, Bogusław Kedra, Maciej Szmitkowski |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 25
Issue 10
Pg. 1177-84
(Oct 2010)
ISSN: 1432-1262 [Electronic] Germany |
PMID | 20556397
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Tumor-Associated, Carbohydrate
- Carcinoembryonic Antigen
- Tissue Inhibitor of Metalloproteinase-1
- Matrix Metalloproteinase 9
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Topics |
- Adenoma
(diagnosis)
- Adult
- Aged
- Aged, 80 and over
- Antigens, Tumor-Associated, Carbohydrate
(analysis)
- Carcinoembryonic Antigen
(analysis)
- Case-Control Studies
- Colorectal Neoplasms
(diagnosis)
- Diagnosis, Differential
- Female
- Humans
- Male
- Matrix Metalloproteinase 9
(blood)
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Tissue Inhibitor of Metalloproteinase-1
(blood)
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