Abstract | CONTEXT: OBJECTIVES: METHODS: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultrasensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria. RESULTS: Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and 0.014 (0.012-0.017) ng/ml in women (P < 0.001). Plasma procalcitonin was positively associated with body mass index and waist circumference. In both sexes, cross-sectional associations of plasma procalcitonin with insulin resistance and components of the MS remained significant after adjustment for age, body mass index, waist circumference, and other covariates. The age-adjusted odds ratio (OR) for MS was 3.2 [95% confidence interval (CI) = 2.5-4.2) in men and 4.1 (95% CI = 3.0-5.5) in women, when comparing the highest with the lowest quartile of plasma procalcitonin. The multivariate-adjusted OR for MS was 1.9 (95% CI = 1.4-2.6) in men and 2.3 (95% CI = 1.6-3.3) in women. The multivariate-adjusted OR for insulin resistance was 3.3 (95% CI = 2.4-4.3) in men and 2.5 (95% CI = 1.9-3.4) in women. CONCLUSIONS:
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Authors | Ali Abbasi, Eva Corpeleijn, Douwe Postmus, Ron T Gansevoort, Paul E de Jong, Rijk O B Gans, Joachim Struck, Hans L Hillege, Ronald P Stolk, Gerjan Navis, Stephan J L Bakker |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 95
Issue 9
Pg. E26-31
(Sep 2010)
ISSN: 1945-7197 [Electronic] United States |
PMID | 20534760
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- CALCA protein, human
- Protein Precursors
- Calcitonin
- Calcitonin Gene-Related Peptide
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Body Mass Index
- Calcitonin
(blood)
- Calcitonin Gene-Related Peptide
- Cross-Sectional Studies
- Female
- Humans
- Insulin Resistance
(physiology)
- Male
- Metabolic Syndrome
(blood, etiology)
- Middle Aged
- Obesity
(blood)
- Protein Precursors
(blood)
- Risk Factors
- Up-Regulation
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