Abstract | BACKGROUND: Serum pro-inflammatory cytokine levels are frequently elevated in the acute phase of pediatric inflammatory bowel disease (IBD). Because the role of pro-inflammatory cytokine in the acute phase of pediatric IBD has not been well investigated, the serum levels of pro-inflammatory cytokines and the expression of Th1 and Th2 signaling molecules in mucosa from the acute phase of pediatric IBD were examined. METHODS: RESULTS: Significant elevation of serum IL-4 and IL-6 levels was detected at the acute phase of pediatric UC and CD compared with levels at remission (P < 0.05 in each). The mucosal expression of GATA-3 and STAT-4 was significantly enhanced in the acute phase of pediatric UC compared with normal mucosa. No significant difference was observed in the expression of all examined molecules in the acute phase of pediatric CD. CONCLUSIONS:
IL-4 and its signaling molecule GATA-3, as well as the Th1 signaling molecule STAT-4, are involved in the pathogenesis of acute phase of pediatric UC.
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Authors | Kiyotaka Ohtani, Yoshikazu Ohtsuka, Tamaki Ikuse, Yosuke Baba, Yoko Yamakawa, Yo Aoyagi, Tohru Fujii, Takahiro Kudo, Satoru Nagata, Toshiaki Shimizu |
Journal | Pediatrics international : official journal of the Japan Pediatric Society
(Pediatr Int)
Vol. 52
Issue 4
Pg. 584-9
(Aug 2010)
ISSN: 1442-200X [Electronic] Australia |
PMID | 20030749
(Publication Type: Journal Article)
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Copyright | © 2010 Japan Pediatric Society. |
Chemical References |
- GATA3 Transcription Factor
- Interleukin-6
- STAT4 Transcription Factor
- STAT4 protein, human
- Interleukin-4
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Topics |
- Acute Disease
- Child
- Colitis, Ulcerative
(metabolism)
- Crohn Disease
(metabolism)
- Female
- GATA3 Transcription Factor
(metabolism)
- Humans
- Interleukin-4
(blood)
- Interleukin-6
(blood)
- Intestinal Mucosa
(metabolism)
- Male
- STAT4 Transcription Factor
(metabolism)
- Signal Transduction
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