Abstract |
Food protein-induced enterocolitis syndrome (FPIES) is a non- IgE-mediated food allergy characterized by severe vomiting, diarrhea, and often failure to thrive in infants. Symptoms typically resolve after the triggering food-derived protein is removed from the diet and recur within few hours after the re-exposure to the causal protein. The diagnosis is based on clinical symptoms and a positive food challenge. In this study, we report a case of FPIES to rice in an 8-month-old boy. We performed a double-blind placebo-controlled food challenge (DBPCFC) to rice and we measured the intracellular T cell expression of interleukin-4 (IL-4); IL-10, and interferon gamma (IFN-gamma) pre-and post-challenge during an acute FPIES reaction and when tolerance to rice had been achieved. For the first time we describe an increase in T cell IL-4 and decrease in IFN-gamma expression after a positive challenge with rice (i.e. rice triggered a FPIES attack) and an increase in T cell IL-10 expression after rice challenge 6 months later after a negative challenge (i.e., the child had acquired tolerance to rice) in an 8 month old with documented FPIES to rice. A Th2 activation associated with high IL-4 levels may contribute to the pathophysiology of the disease. On the other hand, T cell-derived IL-10 may play a role in the acquisition of immunotolerance by regulating the Th1 and Th2 responses.
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Authors | F Mori, S Barni, A Cianferoni, N Pucci, M de Martino, E Novembre |
Journal | Clinical & developmental immunology
(Clin Dev Immunol)
Vol. 2009
Pg. 679381
( 2009)
ISSN: 1740-2530 [Electronic] Egypt |
PMID | 20011655
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Breast Feeding
- CD3 Complex
(biosynthesis)
- Cytokines
(metabolism)
- Diarrhea
- Enterocolitis
(chemically induced, diagnosis, immunology, physiopathology)
- Food Hypersensitivity
(diagnosis, immunology, physiopathology)
- Humans
- Immune Tolerance
- Immunization
- Infant
- Male
- Oryza
(adverse effects, immunology)
- Th1 Cells
(immunology, metabolism, pathology)
- Th2 Cells
(immunology, metabolism, pathology)
- Vomiting
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