Impaired insulin secretion and uptake in patients with diffuse idiopathic skeletal hyperostosis.

Abstract

OBJECTIVE:

So far, high prevalence of metabolic symptoms accompanying diffuse idiopathic skeletal hyperostosis (DISH) appears not definitely elucidated because of their possible origin from other disorders such as diabetes and/or body mass differences. From such reasons this study was aimed to compare non-diabetic DISH patients to a group of age and BMI matched controls in order to distinguish the influence of DISH proper on metabolic parameters free of additional metabolic effects caused by diabetes and/or body weight differences.

METHODS:

Both groups of patients were subjected to oral glucose tolerance test (OGTT) and fasting serum levels of glucose, insulin, C-peptide, growth hormone, insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGF-BP3) were assayed. Fasting serum total cholesterol, HDL cholesterol, triglycerides, non-esterified fatty acids (NEFA) and uric acid were determined as well. The indices of insulin sensitivity and insulin secretion were calculated.

RESULTS:

With the exception of decreased NEFA serum level and decreased insulinogenic index and insulin/C-peptide ratio in DISH patients any other significant differences in serum parameters and indices of insulin sensitivity were not found.

CONCLUSIONS:

The data obtained suggest impaired beta-cell pancreatic stimulation and increased insulin hepatic extraction in DISH. It is assumed that the above mentioned conditions, if persisting for a long time, might lead to decreased ability of insulin to maintain normal serum glucose level and consequently to insulin resistance which is highly prevalent in symptomatic DISH patients.

• Authors: M Eckertova, K Krskova, A Penesova, Z Radikova, D Zlnay, J Rovensky, S Zorad
• Journal: Endocrine regulations (Endocr Regul) Vol. 43 Issue 4 Pg. 149-55 (Oct 2009) ISSN: 1210-0668 [Print] Germany
• PMID: 19908933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• C-Peptide
• Fatty Acids, Nonesterified
• Insulin
• Insulin-Like Growth Factor Binding Protein 3
• Lipids
• Human Growth Hormone
• Insulin-Like Growth Factor I

Topics

• Blood Glucose (analysis)
• C-Peptide (blood)
• Fatty Acids, Nonesterified (blood)
• Female
• Glucose Tolerance Test
• Human Growth Hormone (blood)
• Humans
• Hyperostosis, Diffuse Idiopathic Skeletal (complications, metabolism, physiopathology)
• Insulin (blood, metabolism)
• Insulin Resistance
• Insulin Secretion
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (analysis)
• Insulin-Secreting Cells (physiology)
• Lipids (blood)
• Male
• Metabolic Syndrome (epidemiology, etiology)
• Middle Aged