Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy.

Abstract

Highly active antiretroviral therapy (HAART) contributes to the development of metabolic complications including dyslipidemia, insulin resistance (IR), and lipodystrophy (LD). Recent studies reported that retinol-binding protein 4 (RBP4) is associated with IR, dyslipidemia, and obesity in non-HIV-infected populations. The aim of this study was to evaluate the associations between RBP4 and LD or metabolic abnormalities in HIV-infected subjects receiving HAART. We performed a cross-sectional study with 113 HIV-infected subjects receiving HAART for more than 6 months. Body composition and abdominal fat were measured by bioelectrical impedance analysis and ultrasonography, and fasting serum RBP4 was measured by enzyme-linked immunosorbent assay. Retinol-binding protein 4 levels in subjects with LD were similar to those without LD (P = .839). Retinol-binding protein 4 had significantly positive correlations with waist circumference (r = 0.298, P = .002), waist-to-hip ratio (r = 0.336, P = .001), body mass index (r = 0.310, P = .002), total body fat mass (r = 0.323, P = .001), total cholesterol (r = 0.188, P = .048), log (triglyceride) (r = 0.269, P = .004), and log (homeostasis model assessment of IR) (r = 0.207, P = .036), and negative correlations with quantitative insulin sensitivity check index (r = -0.209, P = .034) after adjustment for age and sex. In stepwise multivariate linear regression analysis, waist-to-hip ratio was the most significant independent predictor of increased RBP4 (standardized beta = .351, P = .001). These results suggest that serum RBP4 is associated with obesity, IR, and dyslipidemia in HIV-infected subjects receiving HAART.

• Authors: Sang Hoon Han, Bum Sik Chin, Han Sung Lee, Su Jin Jeong, Hee Kyoung Choi, Chang Oh Kim, Jun Yong Choi, Young Goo Song, Hyun Chul Lee, June Myung Kim
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 58 Issue 11 Pg. 1523-9 (Nov 2009) ISSN: 1532-8600 [Electronic] United States
• PMID: 19501863 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Lipids
• RBP4 protein, human
• RNA, Viral
• Retinol-Binding Proteins, Plasma

Topics

• Abdomen (diagnostic imaging)
• Adult
• Antiretroviral Therapy, Highly Active
• Blood Glucose (metabolism)
• Blood Pressure (physiology)
• Body Composition (drug effects, physiology)
• Cross-Sectional Studies
• Dyslipidemias (blood, complications)
• Enzyme-Linked Immunosorbent Assay
• Female
• HIV Infections (complications, drug therapy)
• HIV-Associated Lipodystrophy Syndrome (blood, complications)
• Humans
• Insulin Resistance (physiology)
• Lipids (blood)
• Male
• Middle Aged
• Obesity (blood, complications)
• RNA, Viral (blood)
• Retinol-Binding Proteins, Plasma (metabolism)
• Ultrasonography
• Waist Circumference