Retinol-Binding Proteins (Retinoid Binding Proteins)

Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW=80-90 kDa) circulates in plasma in the form of a protein-protein complex with prealbumin. The retinol-binding protein found in tissue has a molecular weight of 14 kDa and carries retinol as a noncovalently bound ligand.

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Networked: 1421 relevant articles (18 outcomes, 156 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kahn, Barbara B: 15 articles (12/2020 - 07/2005)
2.	Blüher, Matthias: 14 articles (01/2021 - 06/2006)
3.	Raila, Jens: 13 articles (09/2020 - 07/2003)
4.	Schweigert, Florian J: 13 articles (05/2018 - 07/2003)
5.	Xia, Min: 10 articles (11/2023 - 08/2013)
6.	Stumvoll, Michael: 10 articles (01/2022 - 07/2007)
7.	Liu, Yan: 9 articles (11/2023 - 08/2013)
8.	Blaner, William S: 9 articles (12/2022 - 12/2007)
9.	Suchdev, Parminder S: 9 articles (01/2021 - 05/2012)
10.	Graham, Timothy E: 8 articles (03/2012 - 07/2005)

Related Diseases

1.	Insulin Resistance 01/01/2014 - "Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren: the Ouro Preto study." 08/01/2013 - "Recent studies have revealed the essential role of retinol binding protein 4 (RBP4) in insulin resistance. " 01/01/2011 - "Retinol-binding protein 4 (RBP4) has been proposed as an early marker for insulin resistance (IR), but no prior studies have addressed RBP4 in an exclusively prepubertal population. " 01/01/2011 - "Assessment of retinol binding protein (RBP-4) seems to be promising because data from animal and human studies suggest its role in the pathomechanism of insulin resistance. " 04/01/2009 - "Recent studies have demonstrated an association between retinol-binding protein (RBP4) and insulin resistance. "
2.	Body Weight (Weight, Body) 12/01/1990 - "The data showed that body weight and retinol-binding protein significantly increased with both G and GL regimens. " 11/01/2007 - "The measurement of body weight and retinol binding protein or transferrin may be useful for nutritional assessment during autologous or allogeneic HSCT, respectively. " 03/01/1990 - "Body-weight, liver weight, and total liver vitamin A stores of undernourished pups were just half those measured for control pups, although serum vitamin A and serum retinol-binding protein were nearly normal in concentration. " 04/01/2007 - "Modification of the enzyme therapy to normalize fat absorption as assessed by the breath test in the second group of 20 patients was associated with a significant increase of body weight (P < .001), and serum concentrations of retinol binding protein (P < .001) and prealbumin (P < .001). " 11/01/2019 - "The nutritional indices, including weight, body length, serum albumin, serum prealbumin, serum retinol-binding protein, and incidence of HAEC after 2-4 successful home rectal irrigation, were used to assess the efficacy of home rectal irrigation. "
3.	Crohn Disease (Crohn's Disease) 08/01/1997 - "After 2 weeks of treatment, there were significant improvements in simple Crohn's disease activity index, erythrocyte sedimentation rate, permeability index, body mass index, prealbumin, retinol binding protein and multiskin test in the elemental diet group. " 10/01/1991 - "It was found that in 15 patients with active ulcerative colitis, 14 patients with active Crohn's disease and in 3 operated patients with recurrent Crohn's disease serum retinol levels and retinol-binding protein were significantly lower than in controls. " 01/01/2021 - "Prealbumin and Retinol-Binding Protein 4: The Promising Inflammatory Biomarkers for Identifying Endoscopic Remission in Crohn's Disease." 08/01/1997 - "In all patients studied, simple Crohn's disease activity index, nutritional status (expressed as body mass index), percentage of ideal body weight, fat mass, fat free mass, erythrocyte sedimentation rate, interleukin-6, intestinal permeability (expressed as permeability index), prealbumin, retinol binding protein and multiskin test were evaluated before and after treatment. " 01/01/1991 - "There was a significant correlation between clearance of alpha 1-antitrypsin and serum levels of retinol-binding protein and transferrin in patients with ulcerative colitis and with retinol-binding protein in patients with Crohn's disease. "
4.	Obesity 01/30/2024 - "Several studies showed the correlation of retinol-binding protein 4 (RBP4) with increased cardiovascular risk - including higher values of carotid intima-media thickness (cIMT) - particularly in individuals with obesity. " 07/01/2007 - "Recent studies have shown that serum retinol-binding protein 4 (RBP4) levels increase with obesity. " 01/30/2024 - "Are variants of the RBP4 gene associated with serum retinol-binding protein 4 concentrations and carotid intima-media thickness values in women with obesity?" 07/01/2022 - "Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)." 01/01/2021 - "Retinol-binding protein 4 in obesity and metabolic dysfunctions."
5.	Neoplasms (Cancer) 03/07/2020 - "Retinol-Binding Protein 4 Accelerates Metastatic Spread and Increases Impairment of Blood Flow in Mouse Mammary Gland Tumors." 08/01/2015 - "Is retinol binding protein 4 a link between adiposity and cancer?" 12/01/2008 - "Urinary retinol-binding protein also tended to associate with previous renal disease, vasculopathy and neoplasm. " 01/01/1993 - "We compared a nephelometric method and a radial immunodiffusion (RID) assay for the measurement of retinol-binding protein in samples of serum from children with malignancies. " 12/01/1985 - "Despite significant differences in retinoid-binding protein levels between tumor and adjacent normal tissue, there was no significant correlation of these differences with any of the patient clinical parameters or any of the tumor growth characteristics. "

Related Drugs and Biologics

1.	Prealbumin (Transthyretin)
2.	Transferrin (beta 2 Transferrin)
3.	Vitamin A (Retinol)
4.	Proteins (Proteins, Gene)
5.	Acetylglucosaminidase (NAGase)
6.	Serum Albumin
7.	Leptin
8.	Albumins
9.	Biomarkers (Surrogate Marker)
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Gastrectomy
2.	Bariatric Surgery
3.	Nutritional Support (Artificial Feeding)
4.	Therapeutics
5.	Adjuvant Chemotherapy