Abstract | BACKGROUND: METHODS: In this cross-sectional analysis, we studied 20 young normal-weight PCOS patients who had received a six-month course of metformin treatment. Ten of these patients remained anovulatory (anovulatory group), whereas other ten became ovulatory, but failed to conceive (ovulatory group). Other ten age- and body mass index (BMI)-matched PCOS subjects were also enrolled as controls and observed without any treatment (control group). RESULTS: After six months of metformin, in both PCOS treated groups, a similar improvement in testosterone (T) and insulin resistance indexes was observed. Moreover, in one (10.0%) and nine (90.0%) subjects from anovulatory and ovulatory PCOS groups, respectively, ovarian morphology changed, whereas a significant reduction in ovarian dimension was observed in the PCOS ovulatory group only. CONCLUSION: PCOS patients under metformin administration demonstrate a change in ovarian morphology closely related to ovulatory response.
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Authors | Angela Falbo, Francesco Orio, Roberta Venturella, Erika Rania, Caterina Materazzo, Achille Tolino, Fulvio Zullo, Stefano Palomba |
Journal | Journal of ovarian research
(J Ovarian Res)
Vol. 2
Pg. 5
(May 31 2009)
ISSN: 1757-2215 [Electronic] England |
PMID | 19480717
(Publication Type: Journal Article)
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