Abstract |
Protective effect of caffeic acid phenethyl ester (CAPE) on ovary ischemia/reperfusion (IR) injury was investigated in this study. Twenty four New Zealand rabbits were divided into 4 groups as follows: group S served as sham. Group C was intraperitoneally injected with CAPE (8.5mg/kg). In groups E+IR and C+IR, 1% ethanol and CAPE was given intraperitoneally before torsion, respectively. Then, the ovaries were subjected to IR in both groups. Ovary reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity in group E+IR were significantly reduced compared to that of group S. GSH level and GSH-Px activity was significantly increased in group C+I/R. Thiobarbituric acid reactive substances ( TBARS) and catalase (CAT) activity in group E+I/R was significantly higher than in group S. CAT activity was decreased to normal levels by CAPE treatment in group C+I/R, while TBARS in group C+IR was significantly reduced compared to that of E+IR. According to histopathological examination, severe congestion, hemorrhage, edema and leukocyte infiltration were observed in E+I/R group. CAPE prominently reduced degenerative effects of IR injury thus it alleviates free radical damage. In conclusion, CAPE which is able to prevent IR-induced injury in the ovaries may be of therapeutic value before the surgical correction.
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Authors | A Kart, Y Cigremis, H Ozen, O Dogan |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 47
Issue 8
Pg. 1980-4
(Aug 2009)
ISSN: 1873-6351 [Electronic] England |
PMID | 19457442
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Caffeic Acids
- Thiobarbituric Acid Reactive Substances
- Catalase
- caffeic acid phenethyl ester
- Glutathione
- Phenylethyl Alcohol
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Topics |
- Animals
- Antioxidants
(metabolism)
- Caffeic Acids
(toxicity)
- Catalase
(metabolism)
- Female
- Glutathione
(metabolism)
- Lipid Peroxidation
(drug effects)
- Ovarian Diseases
(prevention & control)
- Phenylethyl Alcohol
(analogs & derivatives, toxicity)
- Rabbits
- Reperfusion Injury
(prevention & control)
- Thiobarbituric Acid Reactive Substances
(metabolism)
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