Topical administration of diclofenac (1%) in the prevention of miosis during vitrectomy.

Abstract

PURPOSE:

A prospective, randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation.

METHODS:

Fifty consecutive patients undergoing vitrectomy were randomly assigned to diclofenac (n = 24) or control (n = 26) groups. All patients received a standard preoperative regimen of cyclopentolate (2%) and phenylephrine hydrochloride (2.5%). The diclofenac group also received diclofenac (1%) preoperatively. Pupillary diameter was recorded at four time points during surgery. Inflammatory indices were measured postoperatively using slit-lamp examination.

RESULTS:

After induction of anesthesia, the decrease in pupil size was not significantly different between the two groups (P = 0.112), but for the next two stages, it was significantly less in the diclofenac group (P = 0.012 and P = 0.003, respectively). No significant differences were found between the two groups for anterior chamber cells and redness in the eye postoperatively (P = 0.609 and P = 0.123, respectively). However, anterior chamber flare was significantly greater in the control group (P = 0.035), and patients felt significantly more pain in this group (P = 0.001).

CONCLUSIONS:

Topical administration of diclofenac was effective in maintaining mydriasis during vitrectomy and in reducing postoperative pain and anterior chamber flare as determined by slit-lamp evaluations.

• Authors: Ahmad Mirshahi, Ali Djalilian, Fereshte Rafiee, Abed Namavari
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 28 Issue 9 Pg. 1215-20 (Oct 2008) ISSN: 1539-2864 [Electronic] United States
• PMID: 19430389 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Mydriatics
• Diclofenac

Topics

• Administration, Topical
• Adult
• Aged
• Anterior Chamber (drug effects, pathology)
• Diclofenac (administration & dosage)
• Double-Blind Method
• Female
• Humans
• Inflammation (pathology, prevention & control)
• Male
• Middle Aged
• Miosis (prevention & control)
• Mydriatics (administration & dosage)
• Pain, Postoperative (prevention & control)
• Postoperative Complications (pathology, prevention & control)
• Preoperative Care
• Pupil (drug effects)
• Vitrectomy
• Young Adult