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Phenylephrine (Neo-Synephrine)

Subscribe to New Research on Phenylephrine

An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.

Also Known As:

Neo-Synephrine; Phenylephrine Hydrochloride; (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol; Metaoxedrin; Metasympatol; Mezaton; Neosynephrine; Phenylephrine Tannate; Neo Synephrine; Tannate, Phenylephrine; Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-

Networked: 2363 relevant articles (113 outcomes, 192 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Phenylephrine: 2363
        Etilefrine: 75
        berefrine: 6
        lidocaine drug combination phenylephrine: 4
        prilocaine-phenylephrine: 3
        phenylephrine drug combination neomycin dimethindene: 1
        phenyltoloxamine drug combination phenylpropanolamine phenylephrine chlorpheniramine: 1
        phenyltrope: 1
        Rynatan: 1
        2-fluorophenylephrine
        4-fluorophenylephrine
        6-fluorophenylephrine
        C(11)-D2-PHEN
        dolo mobilat
        Glauko-Biciron
        methylphenylephrine
        N-2-nitrobenzylphenylephrine
        neoparyl-framycetin
        nethaprin dospan
        Phaedpharm
        phenylephrine drug combination dextromethorphan chlorphenamine
        phenylephrone
        phenylpropanolamine drug combination phenylephrine chlorpheniramine
        pivalylphenylephrine
        prednefrin
        sanaven
        SK&F 29029
        thiomersal drug combination phenylephrine pentosan sulfuric polyester
- Alcohols: 387
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Phenylephrine: 2363
        Etilefrine: 75
        berefrine: 6
        lidocaine drug combination phenylephrine: 4
        prilocaine-phenylephrine: 3
        phenylephrine drug combination neomycin dimethindene: 1
        phenyltoloxamine drug combination phenylpropanolamine phenylephrine chlorpheniramine: 1
        phenyltrope: 1
        Rynatan: 1
        2-fluorophenylephrine
        4-fluorophenylephrine
        6-fluorophenylephrine
        C(11)-D2-PHEN
        dolo mobilat
        Glauko-Biciron
        methylphenylephrine
        N-2-nitrobenzylphenylephrine
        neoparyl-framycetin
        nethaprin dospan
        Phaedpharm
        phenylephrine drug combination dextromethorphan chlorphenamine
        phenylephrone
        phenylpropanolamine drug combination phenylephrine chlorpheniramine
        pivalylphenylephrine
        prednefrin
        sanaven
        SK&F 29029
        thiomersal drug combination phenylephrine pentosan sulfuric polyester

Experts

1.	Karmazyn, Morris: 12 articles (12/2014 - 11/2004)
2.	Ngan Kee, Warwick D: 7 articles (04/2015 - 04/2002)
3.	Rajapurohitam, Venkatesh: 7 articles (12/2014 - 11/2004)
4.	Behndig, Anders: 7 articles (11/2013 - 04/2004)
5.	Ciriello, John: 6 articles (04/2013 - 04/2003)
6.	Sadoshima, Junichi: 6 articles (02/2013 - 07/2003)
7.	Alonso, María J: 6 articles (01/2013 - 02/2002)
8.	Salaices, Mercedes: 6 articles (01/2013 - 02/2002)
9.	Khaw, Kim S: 5 articles (04/2015 - 03/2004)
10.	Habib, Ashraf S: 5 articles (03/2013 - 01/2010)

Related Diseases

1.	Hypotension (Low Blood Pressure) 09/01/2014 - "Compared with a pure RL preloading, a mixed HES-RL preloading significantly improved prevention of both hypotension and symptomatic hypotension based on early phenylephrine bolus administration and did not induce adverse effects. " 06/01/2012 - "Therefore, phenylephrine is recommended as first line treatment of maternal hypotension. " 09/01/2002 - "Phenylephrine 1.5 mg IM was effective for reducing the incidence of hypotension and avoided adverse effects." 02/01/2012 - "This is largely due to studies suggesting improved fetal acid-base status with the use of phenylephrine as well as the low incidence of hypotension and its related side effects with prophylactic phenylephrine regimens. " 10/01/2015 - "Efficacy of Bolus-dose Phenylephrine for Peri-intubation Hypotension."
2.	Hypertension (High Blood Pressure) 02/01/1991 - "Thus, in developing hypertension, major alterations in diastolic function were observed that were not structurally related, since these changes 1) could be induced in normal dogs by increasing preload and afterload acutely with phenylephrine and 2) were improved during the ensuing stable period of hypertension." 06/01/2009 - "This study quantified the relationship between the phenylephrine method and noninvasive measures of BRS and examined the effects of aging and hypertension on BRS. " 04/01/2005 - "The present study was designed to analyse whether hypertension alters the involvement of cyclooxygenase-2-derived mediators in phenylephrine-induced vasoconstrictor responses. " 02/01/1999 - "The purpose of this study was to investigate the effect of aging versus hypertension on the blood pressure (BP), heart rate, and left ventricular (LV) responses to the alpha1-agonist phenylephrine in humans. " 07/01/1995 - "In confirmation of our previous study, hypertension produced by phenylephrine resulted in the neuronal expression of Fos (a marker of neuronal activation) in the nucleus of the solitary tract, area postrema, the intermediate and caudal parts of the ventrolateral medulla parabrachial complex, and in the central nucleus of the amygdala. "
3.	Bradycardia 05/01/2014 - "In contrast, phenylephrine (PE)-induced rise in MAP evoked markedly attenuated bradycardia with dramatically reduced c-Fos expression in the nucleus tractus solitarius (NTS) of adult OZR compared with LZR. " 04/30/1998 - "The magnitude of the baroreceptor reflex mediated bradycardia, induced by a phenylephrine induced pressor response, was significantly greater in NK1 knockout mice (P < 0.001) compared to heterozygous and wild-type animals. " 11/03/1992 - "Comparable increments in blood pressure evoked by systemic AVP, as opposed to phenylephrine, were associated with significantly greater reflex bradycardia. " 02/01/1988 - "Bradycardia elicited by phenylephrine-induced increases in pressure was significantly greater after NTS injection of [Sar1, Thr8]Ang II. The slope of the pulse interval-arterial pressure relationship was 0.60 +/- 0.09 ms/mm Hg after injection, as compared with 0.42 +/- 0.07 ms/mm Hg before. " 05/01/2012 - "The reduced BRS for bradycardia was associated with a significant decrease in alpha-adrenergic responsiveness to phenylephrine at 60 minutes after PTP1b inhibition. "
4.	Mydriasis 01/01/2007 - "The current study found that mydriasis from phenylephrine, with minimal effect on accommodation, did not result in significant corneal alteration, and corneal topography can be measured after pupil dilation with phenylephrine." 01/01/2007 - "The current study investigates the effect of mydriasis on corneal shape using phenylephrine alone, where phenylephrine has minimal effect on the accommodative system and whether corneal topography can be done after pupil dilation. " 01/01/2015 - "Clinical data examined included age, sex, duration of clinical signs, ancillary diagnostic test results, and time to mydriasis on topical ocular application of 1% phenylephrine. " 01/01/2013 - "We wish to highlight the importance of acknowledging the accompanying effects of topical phenylephrine drops on the eye other than its intended mydriasis. " 04/01/2010 - "2.5% and 10% phenylephrine for mydriasis in diabetic patients with darkly pigmented irides."
5.	Cataract (Cataracts) 07/01/2001 - "The aim of this study was to evaluate the risk-benefit ratio of phenylephrine 10% in comparison to 5% in the daily practice of the cataract-surgery unit in our clinic by clinical assessment and monitoring of biochemical stress parameters. " 04/01/1998 - "This validation study was undertaken to measure the possible underestimation of cataract prevalence in this community study, which may have occurred because of inadequate dilation from phenylephrine alone. " 08/01/2007 - "The use of intra-cameral phenylephrine to prevent floppy iris syndrome during cataract surgery." 07/01/2001 - "Therefore, we recommend the use of phenylephrine 10% in the described dosage as routine medication for cataract surgery." 01/01/1998 - "We recommend the routine use of 2.5% topical aqueous phenylephrine as a mydriatic agent during cataract surgery and acknowledge the role of 10% topical aqueous phenylephrine as an effective mydriatic agent in cases where 2.5% phenylephrine may not be so effective, such as in subjects with darkly pigmented irides."

Related Drugs and Biologics

1.	Norepinephrine (Noradrenaline)
2.	Epinephrine (Adrenaline)
3.	Ephedrine
4.	Oxygen
5.	Tropicamide
6.	Ophthalmic Solutions (Eye Drops)
7.	Cyclopentolate (Cyclogyl)
8.	Clonidine (ST 155)
9.	Isoproterenol (Isoprenaline)
10.	dapiprazole (Rev-Eyes)

Related Therapies and Procedures

1.	Spinal Anesthesia
2.	Cesarean Section (Caesarean Section)
3.	Denervation
4.	Epidural Anesthesia
5.	Anesthesia