Topical Administration

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

Also Known As:

Networked: 791 relevant articles (78 outcomes, 87 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Kietzmann, Manfred: 4 articles (07/2013 - 06/2002)
2.	Bäumer, Wolfgang: 4 articles (07/2013 - 06/2002)
3.	Piomelli, Daniele: 3 articles (09/2015 - 03/2013)
4.	Tokuda, Harukuni: 3 articles (02/2013 - 02/2003)
5.	DeVincenzo, John P: 3 articles (01/2012 - 10/2008)
6.	Yamaguchi, Y: 3 articles (02/2006 - 10/2001)
7.	Hoppmann, Joachim: 3 articles (12/2005 - 06/2002)
8.	Rowan, T G: 3 articles (12/2000 - 08/2000)
9.	Bentley, Ellison: 2 articles (12/2015 - 09/2011)
10.	McLellan, Gillian J: 2 articles (12/2015 - 09/2011)

Related Diseases

1.	Infection 03/01/2014 - "One-dose topical administration of VCM via FG was effective against localized MRSA graft infection without systemic VCM administration. " 02/01/2015 - "Topical administration of analog 120-146 WH, in addition to accelerating corneal wound healing, effectively cleared a corneal infection as a result of P. " 07/01/2015 - "An in vivo test demonstrated that topical administration of EA (4.0 and 8.0 mg/cm(2) ) significantly enhanced the cure rate in a guinea-pig infection model of Trichophyton rubrum. " 10/01/2014 - "In order to treat cutaneous infections, AmB topical administration is a safer therapy because of the low systemic absorption of the drug across mucous membranes. " 09/01/2014 - "The disinfection and isolation guidance was established for perioperative prevention and control of infection, topical administration of ocular agents, reexamination and healthcare instruction, and alternative measures were taken. "
2.	Keratitis 04/01/1995 - "In the mouse model of HSV-1-induced keratitis and encephalopathy, topical administration of OC-I to the mouse cornea produced a significant decrease in virus production in the cornea (mean virus yields: 3.11 log10 PFU in the treated group and 4.37 log10 PFU in the control group) and significant improvement in survival rates (P = 0.01). " 09/01/2004 - "Standard treatment of bacterial keratitis includes topical administration of concentrated antibiotic solutions repeated at frequent intervals in order to reach sufficiently high drug levels in the corneal tissue to inhibit bacterial growth. " 01/01/2001 - "Therapeutic concentrations are achieved in the cornea after topical administration so that the fluoroqinolones have largely replaced combination therapy for the treatment of bacterial keratitis. " 10/01/1990 - "Topical administration of AC-SOD to the LPS-treated cornea markedly inhibited the infiltration of PMNs and suppressed the occurrence of keratitis. " 02/01/2000 - "Topical administration of purified GSH was able to reduce the virus titre in corneal tissue and, at the same time, was effective in reducing the severity and progression of keratitis and conjunctivitis. "
3.	Wounds and Injuries (Trauma) 07/10/2014 - "The data demonstrated that four topical administrations of SLN-rhEGF and NLC-rhEGF significantly improved healing in terms of wound closure, restoration of the inflammatory process, and re-epithelisation grade. " 07/31/2003 - "Following iv (rat) or topical administration to dermal wounds (rabbit), compound 7 was cleared rapidly (t(1/2) = 23 min) from plasma, but slowly (t(1/2) approximately 3 days) from dermal tissue. " 08/01/2012 - "In our animal studies, the implantation of C-PVA nanofibers along with topical administration of growth factor R-Spondin 1 on full thickness wounds created on rats showed 98.6% wound closure after two weeks post-surgery. " 01/01/2012 - "Our study showed that topical administration of SSFLO (1% or 5%) in excisional wounds allowed reepithelialization in 100% of treated animals. " 08/01/2008 - "Therefore, a narrative review of these studies was conducted indicating that there is only weak evidence to support the topical administration of Calendula in acute and chronic wounds. "
4.	Inflammation 07/01/2015 - "The results of the present study suggested that oral or topical administration of HP extract after myringotomy suppressed the inflammation and fibroblastic activity in the lamina propria of the myringotomized TMs of the rats. " 12/08/2015 - "Furthermore, topical administration of active recombinant MMP-8 also accelerated diabetic wound healing as a consequence of complete re-epithelialization, diminished inflammation, and enhanced angiogenesis. " 01/01/2015 - "Results indicated that oral and topical administrations of the two higher doses of SCs had significant effects on macroscopic score of skin inflammation. " 01/01/2015 - "Oral and Topical Administration of ROQUETTE Schizochytrium sp. Alleviate Skin Inflammation and Improve Wound Healing in Mice." 11/01/2014 - "This formulation produced highly significant analgesic and anti-inflammatory effects over the 48-hour time course studied following topical administration in rats with CFA-induced inflammation of the paw. "
5.	Neoplasms (Cancer) 01/01/2015 - "The avian area vasculosa (AV) and the avian chorioallantoic membrane (CAM) are two useful tools for studying both angiogenesis and antiangiogenesis since they are amenable to both intravascular and topical administration of target, agents, are relatively rapid assays, and can be adapted very easily to study angiogenesis-dependent processes, such as tumor growth. " 01/01/2005 - "The CAM is a useful tool to studying angiogenesis because 1) it is amenable to both intravascular and topical administration of study agents, 2) it is a relatively rapid assay, and 3) it can be adapted very easily to study angiogenesis-dependent processes, such as tumor growth. " 08/01/2013 - "Using fluorescence colonoscopy in mice, gGlu-HMRG fluorescent lesions were detected 5 min after topical administration and fluorescence persisted for at least 30 min. Fluorescence guided biopsy revealed all fluorescent lesions that contained cancer or dysplasia (n=16), whereas three out of 12 non-fluorescent lesions contained low grade dysplasia and others did not contain neoplastic histology. " 02/01/2013 - "This is a challenge during formulation of e.g., parenteral preparations for photodynamic cancer therapy, or preparations for local or topical administration in antimicrobial photodynamic therapy. " 04/01/2012 - "These results demonstrate the feasibility of near-infrared NBI to image and demarcate tumor margins during surgical resection using topical administration of targeted GNR."

Related Drugs and Biologics

1.	Cyclosporine (Ciclosporin)
2.	DNA (Deoxyribonucleic Acid)
3.	Ophthalmic Solutions (Eye Drops)
4.	moxifloxacin (Avelox)
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
6.	Biological Markers (Surrogate Marker)
7.	Antigens
8.	brimonidine (Alphagan)
9.	Alkalies
10.	4''-epiacetylamino-4''-deoxyavermectin B1 (eprinomectin)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplants (Transplant)
3.	Catheters
4.	Photochemotherapy (Photodynamic Therapy)
5.	Therapeutics