Effects of Pithecellobium clypearia Benth extract and its main components on inflammation and allergy.

Abstract	The ethanol extract of Pithecellobium clypearia Benth (PCE) was characterized to be rich in polyphenols by HPLC analysis, and investigated for its anti-inflammatory and anti-allergic activities. In our assay, PCE showed anti-inflammatory activity in both acute and auto-immune inflammation animal models. Administration of PCE can effectively inhibit the croton oil-induced ear edema and capillary permeability, the carrageenin-induced paw edema, and the liver injury caused by propionibacterium acnes plus lipopolysaccharide. PCE was also found to possess anti-allergic activity in inhibiting the DNFB-induced delayed hypersensitivity reaction. Meanwhile, seven main components (1-7) from PCE were studied for their effect on histamine release stimulated by compound 48/80 from rat peritoneal mast cells in vitro. Compound 2 ((-)-epigallocatechin-7-gallate), 3 ((-)-5, 7, 3', 4', 5'-pentahydroxyflavan), and 5 ((-)-tetra hydroxyflavan-7-gallate) showed significant inhibition effect on histamine release.
Authors	Li Bao, Xinsheng Yao, Jiekun Xu, Xiaoyu Guo, Hongwei Liu, Hiroshi Kurihara
Journal	Fitoterapia (Fitoterapia) Vol. 80 Issue 6 Pg. 349-53 (Sep 2009) ISSN: 1873-6971 [Electronic] Netherlands
PMID	19427894 (Publication Type: Journal Article)
Chemical References	5,7,3',4',5'-pentahydroxyflavan Anti-Allergic Agents Anti-Inflammatory Agents Benzopyrans Histamine Antagonists Lipopolysaccharides Plant Extracts gallocatechin-7-gallate tetrahydroxyflavan-7-gallate Croton Oil Catechin Carrageenan
Topics	Animals Anti-Allergic Agents (isolation & purification, pharmacology, therapeutic use) Anti-Inflammatory Agents (isolation & purification, pharmacology, therapeutic use) Benzopyrans (isolation & purification, pharmacology) Carrageenan Catechin (analogs & derivatives, isolation & purification, pharmacology) Croton Oil Disease Models, Animal Edema (drug therapy) Fabaceae (chemistry) Histamine Antagonists (isolation & purification, pharmacology) Hypersensitivity (drug therapy) Inflammation (drug therapy) Lipopolysaccharides Liver (drug effects) Male Mast Cells (drug effects) Mice Molecular Structure Plant Extracts (chemistry, pharmacology, therapeutic use) Plant Leaves Plant Stems Propionibacterium acnes Rats

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