Delayed Hypersensitivity (Hypersensitivity, Type IV)

An increased reactivity to specific antigens mediated not by antibodies but by cells.
Also Known As:
Hypersensitivity, Type IV; Hypersensitivity, Delayed; Delayed Hypersensitivities; Hypersensitivities, Delayed; Hypersensitivities, Tuberculin-Type; Hypersensitivities, Type IV; Hypersensitivity, Tuberculin Type; Tuberculin Type Hypersensitivity; Tuberculin-Type Hypersensitivities; Type IV Hypersensitivities; Hypersensitivity, Tuberculin-Type; Tuberculin-Type Hypersensitivity; Type IV Hypersensitivity
Networked: 2608 relevant articles (39 outcomes, 147 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Infection
3. Body Weight (Weight, Body)
4. Contact Dermatitis (Eczema, Contact)
5. Breast Neoplasms (Breast Cancer)


1. Sandborn, William J: 7 articles (05/2010 - 05/2002)
2. Streilein, J Wayne: 6 articles (03/2005 - 06/2002)
3. Romano, A: 5 articles (12/2013 - 03/2001)
4. Streilein, J W: 5 articles (07/2001 - 05/2000)
5. Kezuka, Takeshi: 4 articles (11/2004 - 06/2002)
6. Cadinha, S: 3 articles (01/2014 - 11/2005)
7. Malheiro, D: 3 articles (01/2014 - 11/2005)
8. Baeck, Marie: 3 articles (06/2011 - 12/2008)
9. Goossens, An: 3 articles (06/2011 - 12/2008)
10. Loftus, Edward V: 3 articles (05/2010 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Delayed Hypersensitivity:
1. AntigensIBA
2. Tuberculin (PPD)IBA
3. Dinitrochlorobenzene (DNCB)IBA
4. AntibodiesIBA
5. Complement System Proteins (Complement)IBA
6. Transferrin (beta 2 Transferrin)IBA
7. ZincIBA
8. infliximab (Remicade)FDA Link
9. Immunoglobulins (Immunoglobulin)IBA
10. Serum AlbuminIBA
05/01/1973 - "Further studies of thymus-bone marrow cell synergism in cutaneous manifestations of delayed hypersensitivity to methylated human serum albumin. "
03/01/1986 - "Influence of surgery, age and serum albumin on delayed hypersensitivity."
02/01/1977 - "T-T-cell interactions involved in delayed hypersensitivity (DH) response have been studied by employing delayed foot pad assay to methylated human serum albumin in C57BL/6J mice. "
09/01/2000 - "Twenty-five medical and surgical patients receiving liquid ready-to-use sterile enteral formulas were evaluated prospectively to investigate the relation of diarrhea to serum albumin level, total lymphocyte count, delayed hypersensitivity to purified protein derivative, antibiotic therapy, administration rate and site of enteral formula, and microbial contamination of enteral feeds. "
08/01/1982 - "The statistical comparison between patients with different tumors and controls, between patients with different stages of the same tumor, and between patients treated with or without previous chemical or radiation therapy led to the following conclusions: 1) malnutrition is mainly related to the type and site of origin of the tumor and, in the early stages of disease, is more pronounced in patients with cancer of the esophagus and stomach; 2) except in patients with breast and cervix cancer, malnutrition gets more severe as the disease becomes advanced; 3) chemical or radiation therapy has a variable impact on the nutritional status, but in selected patients it causes a drop in body weight, arm circumference, arm muscle circumference, and peripheral lymphocytes; 4) body weight, cutaneous delayed hypersensitivity and serum albumin are the most commonly altered parameters."

Therapies and Procedures

1. Homologous Transplantation (Allograft)
2. Drug Therapy (Chemotherapy)
3. Aftercare (After-Treatment)
4. PUVA Therapy
5. Mastectomy (Mammectomy)