Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus.
Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: In T2DM patients, pioglitazone was associated with improvement in some measures of left ventricular diastolic function, myocardial glucose uptake, and whole-body insulin sensitivity. The functional changes, however, were not associated with myocardial substrate and high-energy phosphate metabolism.
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Authors | Rutger W van der Meer, Luuk J Rijzewijk, Hugo W A M de Jong, Hildo J Lamb, Mark Lubberink, Johannes A Romijn, Jeroen J Bax, Albert de Roos, Otto Kamp, Walter J Paulus, Robert J Heine, Adriaan A Lammertsma, Johannes W A Smit, Michaela Diamant |
Journal | Circulation
(Circulation)
Vol. 119
Issue 15
Pg. 2069-77
(Apr 21 2009)
ISSN: 1524-4539 [Electronic] United States |
PMID | 19349323
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids
- Glycated Hemoglobin A
- Hypoglycemic Agents
- PPAR alpha
- Sulfonylurea Compounds
- Thiazolidinediones
- Triglycerides
- Phosphocreatine
- glimepiride
- Adenosine Triphosphate
- Metformin
- Pioglitazone
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Topics |
- Adenosine Triphosphate
(metabolism)
- Aged
- Diabetes Complications
(drug therapy, etiology, physiopathology)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Drug Therapy, Combination
- Fatty Acids
(metabolism)
- Glycated Hemoglobin
(analysis)
- Heart
(diagnostic imaging, drug effects, physiopathology)
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology, therapeutic use)
- Insulin Resistance
- Liver
(drug effects, metabolism, pathology)
- Male
- Metabolic Syndrome
(drug therapy, metabolism)
- Metformin
(administration & dosage, pharmacology, therapeutic use)
- Middle Aged
- Myocardium
(metabolism, pathology)
- PPAR alpha
(physiology)
- Phosphocreatine
(metabolism)
- Pioglitazone
- Radionuclide Imaging
- Stroke Volume
(drug effects)
- Sulfonylurea Compounds
(administration & dosage, pharmacology, therapeutic use)
- Thiazolidinediones
(administration & dosage, pharmacology, therapeutic use)
- Triglycerides
(metabolism)
- Ventricular Dysfunction, Left
(drug therapy, etiology)
- Ventricular Remodeling
(drug effects)
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