Abstract | BACKGROUND: METHODS: Ninety-nine HD patients, followed-up for 36 months, and 133 matched controls were genotyped for the two polymorphisms. HD patients' characteristics were age 64 +/- 13 years, males 64%, diabetic 24%, hypertensive 62%, smokers 38%, dyslipidaemic 28%, all undergoing standard HD thrice weekly. RESULTS:
ESRD was strongly associated with the combination of 2G/2G and 6A/6A homozygosity: OR 2.57 (0.95-7.4), P = 0.037, but not with isolated 2G/2G and 6A/6A homozygosity (P = 0.09 and P = 0.11, respectively). Isolated 2G/2G was associated with all-cause mortality risk independently from age, gender, diabetes, hypertension, smoking, dyslipidaemia, C-reactive protein, albumin, dialysis vintage and history of cardio- vascular disease: HR 2.96 (1.29-6.80), P = 0.01. A trend for the association of mortality and isolated 6A/6A homozygosity was also observed: HR 3.01 (0.88-10.26), P = 0.078. Combination of 2G/2G and 6A/6A homozygosity significantly increased the mortality risk in the same Cox regression model: HR 4.69 (1.72-12.81), P = 0.003. CONCLUSIONS: In this study, we demonstrated for the first time that MMP-1 and MMP-3 gene polymorphisms are negative prognostic risk factors for all-cause mortality in HD patients, independently from traditional risk factors. These data may have important implications for better understanding the pathogenesis of the increased mortality in HD patients.
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Authors | Mario Cozzolino, Maria Luisa Biondi, Andrea Galassi, Olivia Turri, Diego Brancaccio, Maurizio Gallieni |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 24
Issue 7
Pg. 2207-12
(Jul 2009)
ISSN: 1460-2385 [Electronic] England |
PMID | 19221176
(Publication Type: Journal Article)
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Chemical References |
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 1
|
Topics |
- Aged
- Female
- Humans
- Male
- Matrix Metalloproteinase 1
(genetics)
- Matrix Metalloproteinase 3
(genetics)
- Middle Aged
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Renal Dialysis
(mortality)
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