Nephro-protective effect of Kangqianling decoction on chronic renal failure rats.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Kangqianling decoction (KQL), the modified formulation of a classical Chinese prescription named Taohongsiwu decoction, was clinically employed to treat renal fibrosis in chronic renal failure.

AIM OF THE STUDY:

The present study was designed to examine whether KQL has a protective effect on renal function in association with transforming growth factor-beta (TGF-beta), angiotensin II (Ang II), tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappaB (NF-kappaB) in rats with 5/6 renal ablation (Nx)-induced chronic renal failure.

RESULTS:

In renal function deterioration progression, the high expression of serum creatinine (Scr), 24-h urine protein and systolic blood pressure were markedly (P<0.05 or P<0.01) restored by KQL, respectively, at 4 and 8 weeks. The increasing expressions of renal Ang II (P<0.05), angiotensin II1-receptor (AT1R) (P<0.05), TNF-alpha (P<0.05), NF-kappaB (P<0.001) and urine TGF-beta1 (P<0.05) were reduced by the treatment of KQL. Immunohistochemical study further confirmed the nephro-protective activity of KQL as compared to the control and Sham group.

CONCLUSIONS:

The results indicate that KQL is able to protect renal function via ameliorating experimental rat renal failure as found in these renal functional parameters.

• Authors: Liqun He, Peicheng Shen, Qiang Fu, Jun Li, Mo Dan, Xiaoyan Wang, Wei Jia
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 122 Issue 2 Pg. 367-73 (Mar 18 2009) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 19146937 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• NF-kappa B
• Proteins
• RNA, Messenger
• Receptor, Angiotensin, Type 1
• Transforming Growth Factor beta1
• Tumor Necrosis Factor-alpha
• kangxianling
• Angiotensin II
• Creatinine

Topics

• Angelica sinensis
• Angiotensin II (metabolism)
• Animals
• Blood Pressure (drug effects)
• Blood Urea Nitrogen
• Creatinine (blood)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Kidney (drug effects, pathology)
• Kidney Failure, Chronic (drug therapy, pathology)
• Magnoliopsida
• NF-kappa B (metabolism)
• Proteins (metabolism)
• RNA, Messenger (metabolism)
• Rats
• Rats, Wistar
• Receptor, Angiotensin, Type 1 (metabolism)
• Salvia miltiorrhiza
• Transforming Growth Factor beta1 (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)
• Ziziphus