Sindbis virus-based measles DNA vaccines protect cotton rats against respiratory measles: relevance of antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and Th1-type cytokines as correlates of immunity.

Abstract	Measles remains an important cause of pediatric morbidity and mortality in developing countries, especially among infants who are too young to receive the current licensed live attenuated measles vaccine. We developed two Sindbis virus DNA vaccines encoding the measles virus hemagglutinin (pMSIN-H) and fusion proteins (pMSINH-FdU) and examined their immunogenicities and protective efficacies when administered alone or followed by the live measles virus vaccine in cotton rats. Neutralizing antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and gamma interferon-secreting T cells developed after priming and increased after boosting. pMSIN-H priming conferred 100% protection against pulmonary measles, whereas pMSINH-FdU protected only in conjunction with the live measles virus vaccine boost.
Authors	Marcela F Pasetti, Karina Ramirez, Aldo Resendiz-Albor, Jeffrey Ulmer, Eileen M Barry, Myron M Levine
Journal	Journal of virology (J Virol) Vol. 83 Issue 6 Pg. 2789-94 (Mar 2009) ISSN: 1098-5514 [Electronic] United States
PMID	19129445 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Viral Cytokines Hemagglutinins, Viral Measles Vaccine Vaccines, DNA Viral Fusion Proteins hemagglutinin protein G, measles virus Interferon-gamma
Topics	Animals Antibodies, Viral (blood, immunology) Antibody-Producing Cells (immunology) Cytokines (immunology) Hemagglutinins, Viral (genetics, immunology) Humans Immunity, Mucosal Immunization, Secondary Immunologic Memory Interferon-gamma (metabolism) Lung (immunology, virology) Measles (prevention & control) Measles Vaccine (genetics, immunology) Measles virus (genetics, immunology) Neutralization Tests Rats Sigmodontinae Sindbis Virus (genetics) Vaccines, DNA (genetics, immunology) Viral Fusion Proteins (genetics, immunology)

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