Abstract | BACKGROUND: The emergence of human monkeypox and the potential use of recombinant variola and monkeypox viruses as biological terrorist agents have necessitated the development of therapeutic and prophylactic therapies. The primary, or index, cases of smallpox and/or human monkeypox will likely be identified by a characteristic rash. Effective biomarkers will be required to monitor disease progression, guide the choice of therapeutic intervention strategies and evaluate their efficacies. To address this we have evaluated several biomarkers of disease in a lethal mousepox model. METHODS: RESULTS: We have used these biomarkers to establish the optimal dosing regimen for treatment and reveal that a single dose of 25 mg/kg of CMX001 can be efficacious at treating lethal mousepox when administered on days 4 or 5 post- infection. This dose significantly reduces ALT, interferon-gamma and DNA copies found in the blood of infected animals. CONCLUSIONS:
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Authors | Scott Parker, Jill Schriewer, Christina Oberle, Alice Robertson, Randall Lanier, George Painter, R Mark Buller |
Journal | Antiviral therapy
(Antivir Ther)
Vol. 13
Issue 7
Pg. 863-73
( 2008)
ISSN: 1359-6535 [Print] England |
PMID | 19043920
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Biomarkers
- DNA, Viral
- Organophosphonates
- brincidofovir
- Interferon-gamma
- Cytosine
- Aspartate Aminotransferases
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Antiviral Agents
(administration & dosage, therapeutic use)
- Aspartate Aminotransferases
(blood)
- Biomarkers
(analysis)
- Cell Line
- Cytosine
(administration & dosage, analogs & derivatives, therapeutic use)
- DNA, Viral
(blood)
- Disease Models, Animal
- Disease Progression
- Ectromelia virus
(pathogenicity)
- Ectromelia, Infectious
(drug therapy, physiopathology, virology)
- Female
- Humans
- Interferon-gamma
(blood)
- Mice
- Organophosphonates
(administration & dosage, therapeutic use)
- Treatment Outcome
- Weight Loss
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