Abstract | OBJECTIVE: The objective of this study was to determine the effects of induced periapical abscesses on pregnant rats. DESIGN: In 1/2 of the animals (n=16), the pulps of the maxillary right molars were exposed to the oral environment, which resulted in a periapical abscess. The other 1/2 (n=16) were sham-operated. 1/2 of the animals of both groups became pregnant 2 weeks later. The pregnancy duration, and weight and number of pups were assessed at delivery. Serum, liver and uterine horn samples were taken from all animals at euthanasia and serum IL-6, endothelin-1, TNF-alpha, IL-10, cortisol and insulin were determined by ELISA. Liver concentrations of IL-6, CRP and IL-6 and uterine horn concentrations of IL-6, vascular endothelial growth factor ( VEGF), TNF-alpha, IL-10 and IL-1-beta were assessed by ELISA. Blood glucose concentrations were determined using a glucometer. Outcome variables were compared by factorial ANOVA, a post hoc Tukey test, and Pearson's correlation test. RESULTS: CONCLUSION:
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Authors | J L Bain, S R Lester, W D Henry, J P Naftel, R B Johnson |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 54
Issue 2
Pg. 162-71
(Feb 2009)
ISSN: 1879-1506 [Electronic] England |
PMID | 18996503
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Blood Glucose
- Inflammation Mediators
- Insulin
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Biomarkers
(metabolism)
- Birth Weight
- Blood Glucose
(metabolism)
- Disease Models, Animal
- Female
- Inflammation Mediators
(metabolism)
- Insulin
(blood)
- Liver
(metabolism)
- Periapical Abscess
(diagnostic imaging, metabolism, physiopathology)
- Pregnancy
- Pregnancy Complications
(diagnostic imaging, metabolism, physiopathology)
- Pregnancy Outcome
- Radiography
- Rats
- Rats, Sprague-Dawley
- Tumor Necrosis Factor-alpha
(blood)
- Uterus
(metabolism)
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