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Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression.

Abstract
Our previous study demonstrated that PPARgamma ligand rosiglitazone prevents gastric carcinogenesis in rats induced by chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this study, we attempted to identify novel anti-cancer mechanisms of rosiglitazone. By examining the gene expression profiles of MNNG-induced and rosiglitazone-treated gastric cancer with Uniset Rat I Bioarray microarray, we identified a gene that showed prominent responses in the rosiglitazone-treated group. The hypertension-related, calcium-regulated gene (HCaRG) was significantly up-regulated in rat gastric carcinoma of the rosiglitazone-treated group when compared with the MNNG group. We further examined HCaRG expression in human gastric cancer and found that the expression of HCaRG was down-regulated in human gastric cancerous tissue. Rosiglitazone markedly induced the expression of HCaRG in the AGS cell line. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
AuthorsBai-Li Chen, Jun Yu, Zhi-Rong Zeng, Wai-Kit Chu, Christine Y P Wong, Yuen-Yee Cheng, Joseph J Y Sung, Pin-Jin Hu, Wai K Leung
JournalOncology reports (Oncol Rep) Vol. 20 Issue 5 Pg. 1093-7 (Nov 2008) ISSN: 1021-335X [Print] Greece
PMID18949406 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Cell Cycle Proteins
  • Commd5 protein, rat
  • Nuclear Proteins
  • Thiazolidinediones
  • Rosiglitazone
  • Methylnitronitrosoguanidine
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Down-Regulation
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Methylnitronitrosoguanidine (toxicity)
  • Nuclear Proteins (biosynthesis, drug effects, genetics)
  • Oligonucleotide Array Sequence Analysis
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rosiglitazone
  • Stomach Neoplasms (drug therapy, metabolism)
  • Thiazolidinediones (pharmacology)
  • Up-Regulation

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