Abstract | BACKGROUND: METHODS: RESULTS: Except for LL-37, mRNA of hBDs, psoriasin, and RNase 7 was significantly higher expressed in AD (n = 42) and/or PV (n = 35) patients when compared to controls (n = 18). While PV lesions showed significantly higher mRNA hBD-2 levels than lesions of AD, the latter was associated with significantly higher mRNA levels of RNase 7 when compared to PV. A significant positive correlation of hBD expression was observed both in AD patients and PV patients. hBD mRNA levels of AD skin correlated with psoriasin and RNase 7 levels. hBD-1 mRNA expression correlated with AD activity and IL-10 mRNA expression. CONCLUSIONS: Most AMPs investigated in this study proved to be overexpressed in AD as well as PV when compared to controls. However, a statistically significant difference in AMP mRNA expression between AD and PV was only found for hBD-2 and RNase 7. A moderate-to-strong linear relationship between the mRNA expression of particular AMPs appears to exist in AD, and to a lesser extent in PV as well.
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Authors | Thilo Gambichler, Marina Skrygan, Nordwig S Tomi, Nick Othlinghaus, Norbert H Brockmeyer, Peter Altmeyer, Alexander Kreuter |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 147
Issue 1
Pg. 17-24
( 2008)
ISSN: 1423-0097 [Electronic] Switzerland |
PMID | 18446049
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2008 S. Karger AG, Basel. |
Chemical References |
- Antimicrobial Cationic Peptides
- RNA, Messenger
|
Topics |
- Adult
- Antimicrobial Cationic Peptides
(biosynthesis)
- Dermatitis, Atopic
(metabolism)
- Female
- Humans
- Male
- Psoriasis
(metabolism)
- RNA, Messenger
(biosynthesis)
- Reverse Transcriptase Polymerase Chain Reaction
- Skin
(chemistry)
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