Abstract | INTRODUCTION: This study aimed to measure the levels of interleukin-18 (IL-18) in inflamed shallow sites and inflamed deep sites in patients with periodontitis and to compare the data with results from inflamed shallow sites in patients with gingivitis. A secondary aim was to examine the composition of the subgingival microbiota in the sampled sites. METHODS: RESULTS: CONCLUSION: Levels of IL-18 were higher in patients with chronic periodontitis compared with patients with gingivitis, even at sites with similar pocket depths. The presence of similar levels of red complex species in gingivitis sites from periodontitis patients and from gingivitis patients suggested that the higher levels of IL-18 were not associated with a different microbial challenge.
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Authors | C M Figueredo, B Rescala, R P Teles, F P Teles, R G Fischer, A D Haffajee, S S Socransky, A Gustafsson |
Journal | Oral microbiology and immunology
(Oral Microbiol Immunol)
Vol. 23
Issue 2
Pg. 173-6
(Apr 2008)
ISSN: 0902-0055 [Print] Denmark |
PMID | 18279187
(Publication Type: Journal Article)
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Chemical References |
- DNA, Bacterial
- Interleukin-18
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Topics |
- Bacteroides
(isolation & purification)
- Case-Control Studies
- Chronic Disease
- DNA, Bacterial
(analysis)
- Dental Plaque
(chemistry)
- Gingival Crevicular Fluid
(chemistry, microbiology)
- Gingivitis
(metabolism, microbiology)
- Humans
- Interleukin-18
(analysis, metabolism)
- Middle Aged
- Nucleic Acid Hybridization
- Periodontitis
(metabolism, microbiology)
- Porphyromonas gingivalis
(isolation & purification)
- Statistics, Nonparametric
- Treponema denticola
(isolation & purification)
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