Chronic Periodontitis

Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.

Also Known As:

Networked: 3931 relevant articles (298 outcomes, 1346 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY)
2.	Periodontal Pocket (Periodontal Pockets)
3.	Periodontitis
4.	Aggressive Periodontitis (Periodontosis)
5.	Inflammation (Inflammations)

Experts

1.	Pradeep, A R: 55 articles (12/2019 - 12/2000)
2.	Feres, Magda: 26 articles (04/2019 - 06/2002)
3.	Atilla, Gül: 24 articles (05/2020 - 01/2002)
4.	Sorsa, Timo: 24 articles (01/2016 - 01/2002)
5.	Emingil, Gülnur: 22 articles (01/2020 - 09/2002)
6.	Duarte, Poliana Mendes: 22 articles (04/2019 - 08/2009)
7.	Naik, Savitha B: 22 articles (12/2017 - 01/2012)
8.	Figueiredo, Luciene Cristina: 19 articles (02/2019 - 07/2005)
9.	Faveri, Marcelo: 19 articles (08/2017 - 11/2006)
10.	Yoshie, Hiromasa: 19 articles (09/2016 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Periodontitis:

1.	ChlorhexidineIBA 05/01/2020 - "Chlorhexidine (gold standard) has a higher inhibitory effect in the case of chronic periodontitis; however, RJ can also be used as an alternative but at higher concentration and lesser dilution. " 03/14/2022 - "In this study, treatment outcomes of chronic periodontitis could be improved by treating the root surface with simultaneous ultrasonic scaling and chlorhexidine irrigation. " 10/01/2015 - "To assess the efficacy of subgingival irrigation with herbal extract (HE) as compared with 0.2% chlorhexidine (CHX) on periodontal health in patients who have been treated for chronic periodontitis, and still have residual pocket of 3-5 mm. This was a controlled, single-blind, randomized study for 3 months. " 03/14/2022 - "To evaluate the integrated efficacy of completely simultaneous ultrasonic scaling and subgingival irrigation with chlorhexidine in chronic periodontitis. " 01/01/2018 - "The aim of this randomized controlled clinical trial was to compare the efficacy of ayurvedic drugs over chlorhexidine in treating chronic periodontitis. "
2.	Metronidazole (Metric)FDA LinkGeneric 07/01/2012 - "The present study developed an experimental metronidazole-based gel and evaluated its efficacy for the adjuvant treatment of chronic periodontitis. " 06/01/2014 - "Treatment of chronic periodontitis may be improved by the adjunctive use of systemic metronidazole." 10/01/2001 - "As a conclusion, the present study does not provide evidence in favour of the routine use of adjunctive metronidazole dental gel in the treatment of adult periodontitis." 07/01/1999 - "The aim of this study was to evaluate the clinical and bacteriological effects of the intrasulcular application of a 1% metronidazole-gel (repeated administrations outdistanced of 7 days weeks long) currently employed in dermatological practice, to observe if a lower concentration of the chemotherapic agent could be equally effective as the 25% formulation in improving the periodontal condition of nine patients with adult periodontitis. " 08/01/1997 - "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis. "
3.	Doxycycline (Periostat)FDA LinkGeneric 11/01/1998 - "The objectives of the studies presented here were to assess the safety and efficacy of the adjunctive administration of sub-antimicrobial-dose doxycycline (SDD) for the treatment of adult periodontitis and to confirm the optimal dosing regimen. " 01/01/2011 - "Therapeutic Efficacy of Subgingivally Delivered Doxycycline Hyclate as an Adjunct to Non-surgical Treatment of Chronic Periodontitis." 02/01/2013 - "Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis." 01/01/2018 - "In this study, the anti-inflammatory effect of subgingivally delivered nanostructured doxycycline gel (nDOX) was evaluated and compared to conventional doxycycline gel (DOX) used as adjunct to scaling and root planning (SRP) in the treatment of moderate chronic periodontitis to reduce probing pocket depth. " 07/01/2013 - "16 one or two wall infrabony defects, in 11 patients suffering from moderate to severe chronic periodontitis, aged 35-60 years, were randomly divided for bone graft, alone (control) and with doxycycline (test) for the study. "
4.	Minocycline (Cyclops)FDA LinkGeneric 02/01/2006 - "Treatment with SRP plus locally delivered minocycline is more effective than SRP alone in male smokers with chronic periodontitis. " 01/01/2015 - "To evaluate the respective or combinatory efficacy of locally delivered 2% minocycline (MO), and scaling and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis (CP). " 08/01/2018 - "This study aimed to evaluate the efficacy of 2% minocycline hydrochloride combined with flap surgery in the treatment of chronic periodontitis. " 01/01/1998 - "The purpose of this study was to investigate the distribution of several periodontopathic bacteria in adult periodontitis, their in vitro susceptibility to minocycline-HCl, and whether the efficacy of the drug changes with a decrease in bacterial susceptibility. " 08/01/1996 - "The objectives of the present study were to establish in a long-term investigation the safety as well as the clinical and microbiological efficacy of scaling and rootplaning combined with local application of 2% minocycline hydrochloride-gel versus placebo-gel in patients with moderate to severe chronic adult periodontitis. "
5.	Anti-Bacterial Agents (Antibiotics)IBA 10/01/2008 - "The adjunctive application of antibiotics improved the treatment outcome in subjects with severe chronic periodontitis. " 01/18/2018 - "Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up." 08/01/2017 - "Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial." 01/01/2015 - "Hence, this study was undertaken to know the nature of oral microbiota in chronic periodontitis in this region of India and also the semiquantitative study in pre- and post-treatment group and to determine antibiotic susceptibility pattern for aerobic isolates. " 01/01/2012 - "The aim of this study is to determine the effectiveness of systemic antibiotics in the management of aggressive and chronic periodontitis. "
6.	Tetracycline (Achromycin)FDA LinkGeneric 07/01/2023 - "The aim of this study was to evaluate clinically and microbiologically the efficacy of tetracycline fibers in conjunction with scaling and root planning in chronic periodontitis patients. " 09/01/2017 - "The present study was conducted with the goal to test an innovative therapeutic option using chemically modified tetracycline in patients affected with generalized, moderate and severe chronic periodontitis. " 07/01/1991 - "The study design and baseline characteristics of a multicenter trial to test the effectiveness and safety of locally delivered tetracycline for treatment of adult periodontitis are described. " 07/01/2023 - "The polyberry gel may thus be used as a safe adjunct to SRP/tetracycline in chronic periodontitis." 11/01/2016 - "Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis."
7.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/01/2020 - "A combination of PDT and SRP gave rise to a significant improvement in clinical and microbiological parameters in patients with chronic periodontitis." 09/01/2016 - "PDT in conjunction with SRP has shown additional improvement in periodontal parameters when compared to SRP alone and has a beneficial effect in chronic periodontitis patients." 02/01/2008 - "Based on these findings, it appears that SRP and SRP with PDT are all effective for chronic periodontitis, but the effect of SRP with PDT may last longer. " 11/01/2016 - "In patients with chronic periodontitis, clinical outcomes of conventional SRP can be improved by adjunctive PDT." 06/01/2021 - "Role of PDT as an adjunct to SRP on whole salivary RANKL and OPG ratio in type-2 diabetic and normoglycemic individuals with chronic periodontitis."
8.	xanthan gum (xanthan)FDA LinkGeneric 07/01/2013 - "Subgingival injection of xanthan-based Chlosite(®) gel adjunct with scaling and root planing appeared to cause significant improvement compared with scaling and root planing alone in persons with chronic periodontitis." 07/01/2013 - "The aim of this study was to evaluate the clinical effectiveness of locally delivered xanthan-based Chlosite(®) gel as an adjunctive therapy to scaling and root planing in treatment of chronic periodontitis. " 07/01/2012 - "The results suggest that the application of xanthan based chlorhexidine gel following SRP in the maintenance phase might be beneficial in treatment of the chronic periodontitis in comparison to SRP alone. " 07/01/2021 - "Efficacy of Xanthan-Based Chlorhexidine Gel on the Levels of Interleukin-1β in Chronic Periodontitis: An Interventional Study." 01/01/2021 - "It is of interest to evaluate the efficacy of xanthan-based chlorhexidine gel (Xan-CHX) in patients with mild-severe chronic periodontitis. "
9.	CurcuminIBA 07/01/2019 - "The local application of curcumin gel when used in conjunction with SRP showed a significant improvement in periodontal parameters and has a beneficial effect in patients with chronic periodontitis. " 12/01/2014 - "Locally delivered 1% curcumin gel was more effective in inhibiting the growth of oral bacteria when used as an adjunct to SRP in the treatment of chronic periodontitis." 08/01/2015 - "Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: A clinical and microbiological study." 11/01/2021 - "The effect of curcumin as an adjunct in the treatment of chronic periodontitis: A systematic review and meta-analysis." 01/01/2019 - "To evaluate sub gingivally applied curcumin gel in treatment of chronic periodontitis based on clinical and biochemical parameters. "
10.	AntioxidantsIBA 12/16/2022 - "Spirulina, a potent antioxidant when administered sub gingivally in pockets can offer improved results in chronic periodontitis patients. " 01/01/2022 - "Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug delivery in the treatment of chronic periodontitis: A placebo-controlled, split-mouth trial." 12/01/2014 - "It is suggested that dietary advice may help to improve dietary habits and, consequently, the antioxidant status of patients with chronic periodontitis. " 12/16/2022 - "Our study concluded that, local drug delivery of Spirulina adjunctive to SRP has potent antioxidant effect in treatment of chronic periodontitis." 01/01/2017 - "Evaluation of oxidative stress in chronic periodontitis patients following systemic antioxidant supplementation: A clinical and biochemical study."

Therapies and Procedures

1.	Root Planing 09/01/2012 - "Scaling and root planing (SRP) is the gold standard treatment for most patients with chronic periodontitis. " 01/01/1989 - "Scaling and root planing followed by regular professional plaque removal are effective in arresting the progress of most chronic adult periodontitis. " 01/01/2020 - "Significant improvement in both clinical and microbiological parameters suggests that subgingival ozonated water irrigation could be an efficient adjunct to scaling and root planing in the treatment of chronic periodontitis." 03/01/2019 - "Scaling and root planing led to an improvement in the clinical parameters and a statistically significant reduction of PTX3 levels (P < 0.05) in both chronic periodontitis groups at the 2-week follow-up, but the changes were greater in the smokers than in the nonsmokers. " 07/01/2019 - "The aim of the study is to compare and evaluate the efficacy of 0.75% BA gel versus 1% CHX gel as an adjunct to scaling and root planing in patients with chronic periodontitis both clinically and microbiologically. "
2.	Therapeutics 01/01/1993 - "Most patients with chronic adult periodontitis exhibited one or two species of organisms at baseline, and these organisms were eliminated or reduced to low levels by mechanical therapy. " 07/01/2016 - "Conventional nonsurgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. " 07/01/2013 - "Conventional non-surgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. " 11/08/2008 - "Non-surgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. " 04/01/2014 - "There was a statistically significant reduction of all sites with attachment loss, the highest significance found at sites where the attachment loss was greater than 5 mm. The results of the study suggest that nonsurgical periodontal therapy is effective in managing the moderate chronic periodontitis. "
3.	Photochemotherapy (Photodynamic Therapy) 01/01/2019 - "This double-blind, randomized, controlled clinical trial assessed the efficacy of multiple sessions of antimicrobial photodynamic therapy (aPDT) as an adjunct to surgical periodontal treatment (ST) in patients with severe chronic periodontitis (SCP). " 02/01/2018 - "Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis." 01/01/2018 - "Comment on "Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis"." 08/01/2019 - "This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis. " 10/01/2008 - "The aim of this study was to assess the effect of adjunctive antimicrobial photodynamic therapy (aPDT) in chronic periodontitis. "
4.	Debridement 05/01/2015 - "Adjunct local antimicrobials provide statistically significant benefits over subgingival debridement alone in patients with chronic periodontitis." 12/01/2016 - "The aim of this study is to evaluate and compare efficacy of open flap debridement (OFD) with or without PRF or PRF + 1.2% RSV gel in treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP). " 09/01/2016 - "The current study is designed to evaluate combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects (IBDs) in individuals with chronic periodontitis (CP). " 06/01/2015 - "The current study is designed to evaluate the efficacy of open-flap debridement (OFD) combined with PRF, 1% MF gel, and PRF + 1% MF gel in the treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP). " 03/01/2013 - "To update the existing scientific evidence on the efficacy of local antimicrobials as adjuncts to subgingival debridement in the treatment of chronic periodontitis. "
5.	Dental Scaling 10/01/2023 - "Clinical comparative study of ultrasonic subgingival scaling and ultrasonic combined with manual subgingival scaling in the treatment of chronic periodontitis." 05/01/2012 - "Scaling root planing (SRP) has been proven efficacious as the traditional treatment approach for chronic periodontitis. " 03/01/2004 - "Twenty-three non-smoking adults with chronic periodontitis received subgingival scaling for 60 minutes. " 05/01/2013 - "To investigate the efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling root planing (SRP) in patients with chronic periodontitis. " 10/01/2012 - "Comparing the efficacy of photoablative and photodynamic diode laser in adjunct to scaling -root planing (SRP) and SRP alone for the treatment of chronic periodontitis. "