You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record).

Abstract

Poly-ubiquitin chains are post-translational modifications commonly used by the ubiquitin-proteasome system to mark proteins for degradation. The regulation of protein degradation plays an important role in regulating muscle cell size, a cellular process balanced by protein synthesis and catabolism. MaFBx/Atrogin-1, a muscle specific F-box protein, is a principle component of the SCF(atrogin-1) ubiquitin ligase complex that ubiquitinates and targets calcineurin for degradation, a key regulatory protein involved in pathologic hypertrophy. We have recently described a novel role for this ubiquitin ligase as a co-activator of the FOXO transcription factors through the catalysis of non-canonical poly-ubiquitin chain formation on FOXO proteins, an event that is sufficient to block Akt-dependent pathways involved in physiologic hypertrophy. In context with other reports describing the regulation and role of FOXO transcription factors, we present a working model for the role of atrogin-1 in both physiologic and pathologic hypertrophy.

• Authors: Jonathan C Schisler, Monte S Willis, Cam Patterson
• Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 7 Issue 4 Pg. 440-3 (Feb 15 2008) ISSN: 1551-4005 [Electronic] United States
• PMID: 18235241 (Publication Type: Journal Article, Review)

Chemical References

• Forkhead Transcription Factors
• Muscle Proteins
• FBXO32 protein, human
• SKP Cullin F-Box Protein Ligases

Topics

• Cardiomegaly (metabolism)
• Forkhead Transcription Factors (metabolism)
• Humans
• Models, Biological
• Muscle Proteins (metabolism)
• Muscles (metabolism)
• SKP Cullin F-Box Protein Ligases (metabolism)
• Signal Transduction (physiology)